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pS351/pS352-CXCR2 (phospho-CXC Chemokine Receptor 2 Antibody)

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 Agonist-induced Serine351/Serine352 phosphorylation of the CXC Chemokine Receptor 2
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  • 7TM0069B
  • 100 µl
  • Rabbit
Serine351/Serine352 (S351/S352) is a major phosphorylation site of the CXCR2 receptor.... more

Serine351/Serine352 (S351/S352) is a major phosphorylation site of the CXCR2 receptor. The pS351/pS352-CXCR2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S351/S352 phosphorylation is a key regulator of CXCR2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CXC-R2, high affinity interleukin-8 Receptor B, Chemokine... more

 

Alternative Names CXC-R2, high affinity interleukin-8 Receptor B, Chemokine (C-X-C motif) Receptor 2
IUPHAR Target ID  69
UniProt ID  P25025
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser351/Ser352.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine351/Serine352 phosphorylation of the CXC Chemokine Receptor 2.... more

Figure 1. Agonist-induced Serine351/Serine352 phosphorylation of the CXC Chemokine Receptor 2. Upper panel, HEK293 cells stably expressing the CXC Chemokine Receptor 2 (CXCR2) were either not exposed or exposed to 100 nM specific CXC Chemokine receptor 2 agonist CXCL6 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS351/pS352-CXCR2 antibody (7TM0069B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CXCR2 antibody to confirm equal loading of the gel.


Be the first to decipher the CXCR2 phosphorylation barcode and let us know. more

Be the first to decipher the CXCR2 phosphorylation barcode and let us know.

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