Immuno-Grade Neurokinin Receptor 1 Antibodies
The tachykinin receptor 1 (NK1, neurokinin receptor 1) is the specific receptor for substance P and with lower affinity for other tachykinin peptides such as neurokinin A (NKA) and neurokinin B (NKB). NK1 is widely distributed in both the central nervous system and peripheral tissues including the substantia nigra, the hypothalamus, the central amygdala, the frontal cortex as well as the gastrointestinal tract. NK1 is the pharmacological target for aprepitant (MK0869; Emend), which is used for post operative/chemotherapy-induced nausea and vomiting. NK1 receptors are also frequently expressed in glioblastomas and breast and pancreatic carcinomas.