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5-HT Receptor Antibodies

5-Hydroxytryptamine (5-HT) receptors are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine (serotonin). 5-HT receptors are distributed amongst seven distinct families, with some families containing multiple receptors, classified primarily on their similar amino acid sequences and structural properties. Further 5-HT receptor heterogeneity is generated through alternative splicing (5-HT3, 5-HT4 and 5-HT7 receptors), RNA editing (5-HT2C receptors) and the putative formation of heterodimers.

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Agonist-induced Threonine343/Serine347/Threonine348 phosphorylation of the 5-Hydroxytryptamine Receptor 4
pT343/pS347/pT348-5-HT4 (phospho-5-HT Receptor...
Threonine343/Serine347/Threonine348 is a major phosphorylation site of the 5-HT4 receptor. The pT343/pS347/pT348-5-HT4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T343/S347/T348...
$ 350.00
NEW
Agonist-induced Serine354/Threonine355 phosphorylation of the 5-Hydroxytryptamine Receptor 4
pS354/pT355-5-HT4 (phospho-5-HT Receptor 4...
Serine354/Threonine355 is a major phosphorylation site of the 5-HT4 receptor. The pS354/pT355-5-HT4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S354/T355 phosphorylation is a key...
$ 350.00

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Hartig PR, Hoyer D, Humphrey PP, Martin GR. Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes. Trends Pharmacol Sci. 1996 Mar;17(3):103-5. doi: 10.1016/0165-6147(96)30002-3. PMID: 8936345.

Fink KB, Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev. 2007 Dec;59(4):360-417. doi: 10.1124/pr.107.07103. Erratum in: Pharmacol Rev. 2008 Mar;60(1):142. PMID: 18160701.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ,... read more »
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5-HT Receptor Antibodies

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Hartig PR, Hoyer D, Humphrey PP, Martin GR. Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes. Trends Pharmacol Sci. 1996 Mar;17(3):103-5. doi: 10.1016/0165-6147(96)30002-3. PMID: 8936345.

Fink KB, Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev. 2007 Dec;59(4):360-417. doi: 10.1124/pr.107.07103. Erratum in: Pharmacol Rev. 2008 Mar;60(1):142. PMID: 18160701.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

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