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pS364-β2 (phospho-β2-Adrenoceptor Antibody)

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Agonist-induced Serine364 phosphorylation of the β2-Adrenoceptor
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  • 7TM0029F
  • 100 µl
  • Rabbit
Serine364 (S364) is a major phosphorylation site of the β2 adrenoceptor. The pS364-β2 antibody... more

Serine364 (S364) is a major phosphorylation site of the β2 adrenoceptor. The pS364-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S364 phosphorylation is primarily mediated by GRK2 and is a key regulator of β2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names β2,B2AR, ADRB2R, β2 Adrenergic... more

 

Alternative Names β2,B2AR, ADRB2R, β2 Adrenergic Receptor, β2-Adrenoceptor
IUPHAR Target ID  29
UniProt ID  P07550
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human β2 around the phosphorylation site of Ser364.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine364 phosphorylation of the β2-Adrenoceptor. Upper panel,... more

Figure 1. Agonist-induced Serine364 phosphorylation of the β2-Adrenoceptor. Upper panel, HEK293 cells stably expressing the β2-Adrenoceptor (β2) were either not exposed or exposed to 1 µM of specific β2-adrenoceptor agonist Isoprenaline for 30 minutes. Cells were lysed and immunoblotted with the anti-pS364-β2 antibody (7TM0029F) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-β2 antibody (7TM0029N) at a dilution of 1:1000 to confirm equal loading of the gel.




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