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Bombesin Receptor Antibodies

Mammalian bombesin receptors (BB) comprise 3 subtypes: BB1, BB2, BB3. BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-releasing peptide (GRP), and GRP-(18-27). Bombesin is a tetra-decapeptide, originally derived from amphibians. The three BB receptor subtypes couple primarily to the Gq/11 and G12/13 family of G proteins. Activation of BB1 and BB2 receptors causes a wide range of physiological actions including the stimulation of cell growth, smooth-muscle contraction, feeding behavior, regulation of circadian rhythm, body temperature control and mediation of pruritus. A physiological role for the BB3 receptor has yet to be fully defined although recently studies suggest an important role metabolic homeostasis and obesity. BB receptors are one of the most frequently overexpressed GPCRs in cancer.

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Agonist-induced Threonine359/Serine360 phosphorylation of the Bombesin Receptor 2
pT359/pS360-BB2 (phospho-Bombesin Receptor 2...
Threonine359/Serine360 (T359/S360) is major phosphorylation site of the Bombesin Receptor 2 (BB2). The pT359/pS360-BB2 antibody detects phosphorylation in response to agonists. T359/S360 phosphorylation is likely to be involved in...
$ 350.00
NEW
 Agonist-induced Serine363/Threonine364 phosphorylation of the Bombesin Receptor 2
pS363/pT364-BB2 (phospho-Bombesin Receptor 2...
Serine363/Threonine364 (S363/T364) is major phosphorylation site of the Bombesin Receptor 2 (BB2). The pS363/pT364-BB2 antibody detects phosphorylation in response to agonists. S363/T364 phosphorylation is likely to be involved in...
$ 350.00
Citations
Validation of the Bombesin Receptor 2 in transfected HEK293 cells
BB2 (non-phospho), Bombesin Receptor 2 Antibody
The BB2/GRPR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Bombesin Receptor 2 (previously called Gastrin-Releasing Peptide Receptor). It can be used to detect total BB2 receptors in Western...
$ 350.00

For more information on bombesin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab. 2016 Sep;27(9):603-605. doi: 10.1016/j.tem.2016.03.003. Epub 2016 Apr 4. PMID: 27055378; PMCID: PMC4992652.

For more information on bombesin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Jensen RT, Battey JF, Spindel ER, Benya RV. International... read more »
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Bombesin Receptor Antibodies

For more information on bombesin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab. 2016 Sep;27(9):603-605. doi: 10.1016/j.tem.2016.03.003. Epub 2016 Apr 4. PMID: 27055378; PMCID: PMC4992652.

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