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Bombesin Receptor 2 Antibodies

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Agonist-induced Threonine359/Serine360 phosphorylation of the Bombesin Receptor 2
pT359/pS360-BB2 (phospho-Bombesin Receptor 2...
Threonine359/Serine360 (T359/S360) is major phosphorylation site of the Bombesin Receptor 2 (BB2). The pT359/pS360-BB2 antibody detects phosphorylation in response to agonists. T359/S360 phosphorylation is likely to be involved in...
$ 350.00
NEW
 Agonist-induced Serine363/Threonine364 phosphorylation of the Bombesin Receptor 2
pS363/pT364-BB2 (phospho-Bombesin Receptor 2...
Serine363/Threonine364 (S363/T364) is major phosphorylation site of the Bombesin Receptor 2 (BB2). The pS363/pT364-BB2 antibody detects phosphorylation in response to agonists. S363/T364 phosphorylation is likely to be involved in...
$ 350.00
Citations
Validation of the Bombesin Receptor 2 in transfected HEK293 cells
BB2 (non-phospho), Bombesin Receptor 2 Antibody
The BB2/GRPR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Bombesin Receptor 2 (previously called Gastrin-Releasing Peptide Receptor). It can be used to detect total BB2 receptors in Western...
$ 350.00

BB2

The BB2 receptor has a 50-fold higher affinity for gastrin-releasing peptide (GRP) than for neuromedin B (NMB). The human BB2 receptor is a 384 amino acid protein and shows a high degree of homology with the mouse receptor. The highest levels of the BB2 receptor are in the pancreas, with lesser amounts in the stomach, prostate, skeletal muscle and CNS. In the gastrointestinal tract BB2 receptor activation causes stimulation of acid secretion, as well as pancreatic and intestinal secretion and stimulates gastrointestinal motility causing gallbladder contraction. In addition to stimulating tissues directly by interacting with BB2 receptors, GRP stimulates the release of a large number of hormones and neurotransmitters (cholecystokinin, gastrin, somatostatin, pancreatic glucagon, insulin, enteroglucagon, neurotensin, gastric inhibitory polypeptide) which can also have potent effects. Numerous studies demonstrate that BB2 receptors play a number of important roles in various processes in the CNS including regulation of circadian rhythm, body temperature control, grooming behaviours, modulation of fear, stress and anxiety, memory as well as pruritic responses. BB2 receptors are one of the most frequently over-expressed or ectopically expressed receptors on human cancers. BB2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine359/serine360 (pT359/pS360-BB2) and serine363/threonine364 (pS363/pT364-BB2). This nomenclature refers to the human BB2 receptor. This phosphorylation motif is highly conserved across species but corresponds to pT360/pS361-BB2 and pS364/pT365-BB2 in mice and rats. For more information on BB2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

The BB2 receptor has a 50-fold higher affinity for gastrin-releasing peptide (GRP) than for neuromedin B (NMB). The human BB2 receptor is a 384 amino acid protein and shows a high degree of... read more »
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Bombesin Receptor 2 Antibodies

BB2

The BB2 receptor has a 50-fold higher affinity for gastrin-releasing peptide (GRP) than for neuromedin B (NMB). The human BB2 receptor is a 384 amino acid protein and shows a high degree of homology with the mouse receptor. The highest levels of the BB2 receptor are in the pancreas, with lesser amounts in the stomach, prostate, skeletal muscle and CNS. In the gastrointestinal tract BB2 receptor activation causes stimulation of acid secretion, as well as pancreatic and intestinal secretion and stimulates gastrointestinal motility causing gallbladder contraction. In addition to stimulating tissues directly by interacting with BB2 receptors, GRP stimulates the release of a large number of hormones and neurotransmitters (cholecystokinin, gastrin, somatostatin, pancreatic glucagon, insulin, enteroglucagon, neurotensin, gastric inhibitory polypeptide) which can also have potent effects. Numerous studies demonstrate that BB2 receptors play a number of important roles in various processes in the CNS including regulation of circadian rhythm, body temperature control, grooming behaviours, modulation of fear, stress and anxiety, memory as well as pruritic responses. BB2 receptors are one of the most frequently over-expressed or ectopically expressed receptors on human cancers. BB2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine359/serine360 (pT359/pS360-BB2) and serine363/threonine364 (pS363/pT364-BB2). This nomenclature refers to the human BB2 receptor. This phosphorylation motif is highly conserved across species but corresponds to pT360/pS361-BB2 and pS364/pT365-BB2 in mice and rats. For more information on BB2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

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