Atypical Chemokine Receptor 2 Antibodies
The atypical chemokine receptor 2 (ACKR2) acts as chemokine scavenger (also known as chemokine decoy receptor) to downregulate inflammation or shape chemokine gradients. ACKR2 can sequester a broad range of chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Efficient ligand uptake by ACKR2 involves phosphorylation of carboxyl-terminal serine348/serine350 (pS348/pS350-ACKR2). This nomenclature refers to the human ACKR2. This phosphorylation motif is highly conserved across species including mouse, rat and human but corresponds to pS344/pS346-ACKR2 in mice. For more information on ACKR2 pharmacology please refer to the IUPHAR database. For further reading refer to:
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