pS348/pS350-ACKR2 (phospho-Atypical Chemokine Receptor 2 Antibody)

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Order number: 7TM0314A
Content: 100 µl
Host: Rabbit

Serine348/Serine350 (S348/S350) is major phosphorylation site of the Atypical Chemokine Receptor... more

Serine348/Serine350 (S348/S350) is major phosphorylation site of the Atypical Chemokine Receptor 2 (ACKR2). The pS348/pS350-ACKR2 antibody detects phosphorylation in response to agonists. S348/S350 phosphorylation is likely to be involved in efficient ligand sequestration by ACKR2.

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Alternative Names ACKR2, Atypical Chemokine Receptor 2 IUPHAR Target... more

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Alternative Names	ACKR2, Atypical Chemokine Receptor 2
IUPHAR Target ID	314
UniProt ID	O00590
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human ACKR2 around the phosphorylation site of Ser348/Ser350
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine348/Serine350 phosphorylation of the Atypical Chemokine... more

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Figure 1. Agonist-induced Serine348/Serine350 phosphorylation of the Atypical Chemokine Receptor 2. Upper left panel, HEK293 cells stably expressing the Atypical Chemokine receptor 2 (ACKR2) were either not exposed or exposed to 100 nM CCL-2 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS348/pS350-ACKR2 antibody (7TM0314A) at a dilution of 1:1000. Upper right panel, same treatment as in upper left panel but cells were additionally treated with λ-phosphatase (λ-PPase). Lower panels, blots were stripped and reprobed with the phosphorylation-independent anti-ACKR2 antibody (7TM0314N-WB) to confirm equal loading of the gel. Note that basal and agonist induced Serine348/Serine350 phosphorylation is abbolished by λ-PPase treatment.

Be the first to analyze the ACKR2 phosphorylation using our anti-pS348/pS350-ACKR2... more

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Be the first to analyze the ACKR2 phosphorylation using our anti-pS348/pS350-ACKR2 antibody and let us know.

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