Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 Antibodies
The atypical chemokine receptor 3 (ACKR3, previously called CXC chemokine receptor 7) is a member of the heptahelical receptor superfamily that sequesters its ligands CXCL11 and CXCL12 by highly efficient internalization. While ACKR3 does not engage heterotrimeric G proteins, it regulates the amount of ligand available for CXCR4. ACKR3 and CXCR4 cooperate in the regulation of many chemokine-dependent processes such as directed cell migration, immune homeostasis, inflammation and cancer. Efficient ligand sequestration by ACKR3 critically depends on GRK2 and GRK5 mediated phosphorylation of carboxyl-terminal serine350/threonine352 (pS350/pT352-ACKR3/CXCR7) but not on β-arrestin recruitment. This phosphorylation motif is highly conserved across a variety of species including mouse, rat and human. For more information on ACKR3 pharmacology please refer to the IUPHAR database. For further reading refer to:
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Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.
Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012 Aug 17;287(34):28362-77. doi: 10.1074/jbc.M111.335679. Epub 2012 Jun 26. PubMed PMID: 22736769; PubMed Central PMCID: PMC3436560.