CXC Chemokine Receptor 6 Antibodies
The CXC chemokine receptor 6 (CXCR6) CXCR6 has a monogamous relationship with CXCL16, which can be found in both membrane-bound and soluble forms. CXCR6 is expressed on T cells as well as on NKT cells, NK cells and plasma cells. CXCR6 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine320/serine321 (pS320/pS321-CXCR6), serine325/threonine327 (pS325/pT327-CXCR6) and serine329/serine331 (pS329/pS331-CXCR6) residues. This nomenclature refers to the human CXCR6. This phosphorylation motif is highly conserved across species and is also present in mice and rats. For more information on CXCR6 pharmacology please refer to the IUPHAR database. For further reading refer to:
Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.