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Cholecystokinin Receptor Antibodies

Cholcystokinin receptors are activated by the endogenous peptides cholecystokinin (CCK-8, -33, -58) and gastrin. There are two distinct receptor subtypes now called CCK1 and CCK2 receptors. They were previously classified as Type A (alimentary) and B (brain), respectively, based on their prominent locations. The CCK receptor subtypes are distinguished by their peptide selectivity. CCK1 receptor requires the carboxyl-terminal heptapeptide-amide that includes a sulfated tyrosine for high affinity and potency. CCK2 receptor requires only the carboxyl-terminal tetrapeptide shared by each CCK and gastrin peptides. The physiological roles for CCK relate to nutritional homeostasis, with activities to stimulate gallbladder contraction, pancreatic exocrine secretion, gastric emptying, intestinal transit, and satiety. The major physiological role for gastrin is the stimulation of gastric acid secretion. Agonist stimulation normally leads to stimulation of phospholipase C and increases in intracellular calcium by coupling to Gq proteins.  Potential therapeutic areas being considered for CCK antagonists include anxiety, nociception, appetite control, depression, learning, memory, neuroprotection, drug dependence, and gastrointestinal dysmotility states. None of these agents are currently approved for standard clinical use.

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Citations
 Validation of the Cholecystokinin Receptor 2 in transfected HEK293 cells
CCK2 (non-phospho), Cholecystokinin Receptor 2...
The CCK2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Cholecystokinin Receptor 2 (previously called CCKB). It can be used to detect total CCK2 receptors in Western blots independent of...
$ 250.00
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pT427/pS429-CCK2 (phospho-Cholecystokinin Receptor 2 Antibody)
pT427/pS429-CCK2 (phospho-Cholecystokinin...
Threonine427/Serine429 (T427/S429) is a major phosphorylation site of the CCK2 receptor. The pT427/pS429-CCK2 antibody detects phosphorylation in response to high-efficacy agonists. T427/S429 phosphorylation is a key regulator of CRF1...
$ 350.00
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pS437/pT439-CCK2 (phospho-Cholecystokinin Receptor 2 Antibody)
pS437/pT439-CCK2 (phospho-Cholecystokinin...
Serine437/Threonine439 (S437/T439) is a major phosphorylation site of the CCK2 receptor. The pS437/pT439-CCK2 antibody detects phosphorylation in response to high-efficacy agonists. S437/T439 phosphorylation is a key regulator of CCK2...
$ 350.00
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pT408/pT409-CCK1 (phospho-Cholecystokinin Receptor 1 Antibody)
pT408/pT409-CCK1 (phospho-Cholecystokinin...
Threonine408/Threonine409 (T408/T409) is a major phosphorylation site of the CCK1 receptor. The pT408/pT409-CCK1 antibody detects phosphorylation in response to high-efficacy agonists. T408/T409 phosphorylation is a key regulator of CCK1...
$ 350.00
NEW
pS412/pS414-CCK1 (phospho-Cholecystokinin Receptor 1 Antibody)
pS412/pS414-CCK1 (phospho-Cholecystokinin...
Serine412/Serine414 (S412/S414) is a major phosphorylation site of the CCK1 receptor. The pS412/pS414-CCK1 antibody detects phosphorylation in response to high-efficacy agonists. S412/S414 phosphorylation is a key regulator of CCK1...
$ 350.00
Citations
Validation of the Cholecystokinin Receptor 1 in transfected HEK293 cells
CCK1 (non-phospho), Cholecystokinin Receptor 1...
The CCK1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Cholecystokinin Receptor 1 (previously called CCKA). It can be used to detect total CCK1 receptors in Western blots independent of...
$ 350.00
NEW
pS417/pS419-CCK1 (phospho-Cholecystokinin Receptor 1 Antibody)
pS417/pS419-CCK1 (phospho-Cholecystokinin...
Serine417/Serine419 (S417/S419) is a major phosphorylation site of the CCK1 receptor. The pS417/pS419-CCK1 antibody detects phosphorylation in response to high-efficacy agonists. S417/S419 phosphorylation is a key regulator of CCK1...
$ 350.00

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev. 1999 Dec;51(4):745-81. Erratum in: Pharmacol Rev 2000 Mar;52(1):177. PMID: 10581329.

Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev. 2006 Jul;86(3):805-47. doi: 10.1152/physrev.00014.2005. PMID: 16816139.

Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J. Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on chemokine receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB,... read more »
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Cholecystokinin Receptor Antibodies

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev. 1999 Dec;51(4):745-81. Erratum in: Pharmacol Rev 2000 Mar;52(1):177. PMID: 10581329.

Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev. 2006 Jul;86(3):805-47. doi: 10.1152/physrev.00014.2005. PMID: 16816139.

Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J. Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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