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Complement Peptide Receptor Antibodies

Complement peptide receptors are activated by a small peptide fragments called C3a, C5a and C5adesArg (previously called anaphylatoxins) that are produced by the complement cascade. Complement peptides are potent chemoattractants and secretagogues that act on immune and non-immune cells. The physiological effects of complement peptides are mediated by a family of three seven transmembrane receptors (7TMRs) designated as C3a, C5a1 and C5a2. While C3a and C5a1 are classical G protein-coupled receptors (GPCRs), C5a2 appears to be permanently uncoupled from G proteins. However,  both C5a1 and C5a2 are required for full pro-inflammatory responses.

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Agonist-induced Threonine324/Serine327 phosphorylation of the Complement C5a Receptor 1.
pT324/pS327-C5a1 (phospho-Complement C5a...
Threonine324/serine327 (T324/S327) is a major phosphorylation site of the C5a1 receptor. The pT324/pS327-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T324/S327...
$ 350.00
NEW
Agonist-induced Serine332/Serine334 phosphorylation of the Complement C5a Receptor 1.
pS332/pS334-C5a1 (phospho-Complement C5a...
Serine332/serine334 (S332/S334) is a major phosphorylation site of the C5a1 receptor. The pS332/pS334-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S332/S334...
$ 350.00
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Validation of the Complement C5a Receptor 1 in transfected HEK293 cells.
C5a1 (non-phospho), Complement C5a Receptor 1...
The non-phospho-C5a1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human C5a1. It can be used to detect total C5a1 receptors in Western blots independent of phosphorylation. The non-phospho-C5a1...
$ 350.00
NEW
Validation of the Complement C5a Receptor 2 in transfected HEK293 cells.
C5a2 (non-phospho), Complement C5a Receptor 2...
The non-phospho-C5a2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human C5a2. It can be used to detect total C5a2 receptors in Western blots independent of phosphorylation. The non-phospho-C5a2...
$ 250.00
NEW
Agonist-induced Serine326/Threonine327 phosphorylation of the Complement C5a Receptor 2.
pS326/pT327-C5a2 (phospho-Complement C5a...
Serine326/Threonine327 (S326/T327) is major phosphorylation site of the Complement Peptide Receptor 2 (C5a2). The pS326/pT327-C5a2 antibody detects phosphorylation in response to agonists. S326/S327 phosphorylation is likely to be...
$ 350.00
NEW
Agonist-induced Threonine336 phosphorylation of the Complement C5a Receptor 1
pT336-C5a1 (phospho-Complement C5a Receptor 1...
Threonine336 (T336) is a major phosphorylation site of the C5a1 receptor. The pT336-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T336 phosphorylation is a key...
$ 350.00
NEW
pS338/pT339-C5a1 (phospho-Complement C5a Receptor 1 Antibody)
pS338/pT339-C5a1 (phospho-Complement C5a...
Serine338/Threonine339 (S338/T339) is a major phosphorylation site of the C5a1 receptor. The pS338/pT339-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S338/T339...
$ 350.00
NEW
Agonist-induced Threonine342 phosphorylation of the Complement C5a Receptor 1
pT342-C5a1 (phospho-Complement C5a Receptor 1...
Threonine342 (T342) is a major phosphorylation site of the C5a1 receptor. The pT342-C5a1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T342 phosphorylation is a key...
$ 350.00

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Klos A, Wende E, Wareham KJ, Monk PN. International... read more »
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Complement Peptide Receptor Antibodies

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

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