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C5a Complement Peptide Receptor 2 Antibodies

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Validation of the Complement C5a Receptor 2 in transfected HEK293 cells.
C5a2 (non-phospho), Complement C5a Receptor 2...
The non-phospho-C5a2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human C5a2. It can be used to detect total C5a2 receptors in Western blots independent of phosphorylation. The non-phospho-C5a2...
$ 250.00
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Agonist-induced Serine326/Threonine327 phosphorylation of the Complement C5a Receptor 2.
pS326/pT327-C5a2 (phospho-Complement C5a...
Serine326/Threonine327 (S326/T327) is major phosphorylation site of the Complement Peptide Receptor 2 (C5a2). The pS326/pT327-C5a2 antibody detects phosphorylation in response to agonists. S326/S327 phosphorylation is likely to be...
$ 350.00

C5a2

C5a2 is a receptor for chemotactic and inflammatory C3a and C5a anaphylatoxin peptides and their dearginated forms C3adesArg and C5adesArg, respectively. Unlike the C5a1 receptor, the C5a2 receptor appears to be permanently uncoupled from G proteins. Activation of both C5a1 and C5a2 is required for full pro-inflammatory responses. C5a2 can sequester complement peptides by highly efficient internalization. Efficient ligand uptake by C5a2 critically depends on phosphorylation of carboxyl-terminal serine326/threonine327 (pS326/pT327-C5a2). For more information on C5a2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

C5a2 is a receptor for chemotactic and inflammatory C3a and C5a anaphylatoxin peptides and their dearginated forms C3adesArg and C5adesArg, respectively. Unlike the C5a1 receptor, the C5a2... read more »
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C5a Complement Peptide Receptor 2 Antibodies

C5a2

C5a2 is a receptor for chemotactic and inflammatory C3a and C5a anaphylatoxin peptides and their dearginated forms C3adesArg and C5adesArg, respectively. Unlike the C5a1 receptor, the C5a2 receptor appears to be permanently uncoupled from G proteins. Activation of both C5a1 and C5a2 is required for full pro-inflammatory responses. C5a2 can sequester complement peptides by highly efficient internalization. Efficient ligand uptake by C5a2 critically depends on phosphorylation of carboxyl-terminal serine326/threonine327 (pS326/pT327-C5a2). For more information on C5a2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

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