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pS434/pS437-CRF1 (phospho-Corticotropin-Releasing Factor Receptor 1 Antibody)

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Agonist-induced Serine434/Serine437 phosphorylation of CRF1 Receptor
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  • 7TM0212C
  • 100 µl
  • Rabbit
Serine434/Serine441 (S437/S441) is a major phosphorylation site of the CRF1 receptor.... more

Serine434/Serine441 (S437/S441) is a major phosphorylation site of the CRF1 receptor. The pS434/pS437-CRF1 antibody detects phosphorylation in response to high-efficacy agonists. S434/S437 phosphorylation is a key regulator of CRF1 desensitization, β-arrestin recruitment and internalization. S434/S437 also undergoes constitutive phosphorylation.

  Alternative Names CRFR1, CRH-R1, CRF-1R alpha, Corticotropin-Releasing... more

 

Alternative Names CRFR1, CRH-R1, CRF-1R alpha, Corticotropin-Releasing Factor Receptor 1
IUPHAR Target ID  212
UniProt ID  P34998
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CRF1 around the phosphorylation site Ser434/Ser437.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced and Agonist-independent Serine434/Serine437 phosphorylation of CRF1... more

Figure 1. Agonist-induced and Agonist-independent Serine434/Serine437 phosphorylation of CRF1 Receptor. Upper panel, HEK293 cells stably expressing the CRF1-Receptor (CRF1) were either not exposed or exposed to 1 µM of specific CRF-Receptor agonist CRH for 30 minutes. Cells were lysed and immunoblotted with the anti-pS434/pS437-CRF1 antibody (7TM0212C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with a phosphorylation-independent anti-CRF1 antibody to confirm equal loading of the gel.

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