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Dopamine Receptor Antibodies

Dopamine is the predominant catecholamine transmitter in the central nervous system that controls locomotor activity, motivation, positive reinforcement and hormonal regulation by interacting with a family of five G protein-coupled receptors (GPCRs) designated D1-D5. Based on structural and functional differences dopamine receptors were divided into the D1-like and D2-like subfamilies. D1-like receptors include D1 and D5, which stimulate cAMP production by coupling to stimulatory G proteins. The D2-like receptors include D2, D3 and D4, which inhibit cAMP production by coupling to inhibitory G proteins. The D2 receptor is a pharmacological target for drugs widely used to treat symptoms for disorders associated with dopaminergic dysfunctions, including Parkinson’s disease and schizophrenia.

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Agonist-induced Threonine317/Serine318 phosphorylation of the Dopamine Receptor 2.
pT317/pS318-D2 (phospho-Dopamine Receptor 2...
Threonine317/serine318 (T317/S318) is a major phosphorylation site of the D2 dopamine receptor. The pT317/pS318-D2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T317/S318...
$ 350.00
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Validation of the Dopamine Receptor 2 in transfected HEK293 cells.
D2 (non-phospho), Dopamine Receptor 2 Antibody
The non-phospho-D2 receptor antibody is directed against the third intracellular loop of mouse, rat and human D2 dopamine receptor. It detects both the long and short form of D2. It can be used to detect total D2 receptors in Western...
$ 350.00
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Agonist-induced Threonine354 phosphorylation of the Dopamine Receptor 1
pT354-D1 (phospho-Dopamine Receptor 1 Antibody)
Threonine354 (T354) is a major phosphorylation site of the D1 receptor. The pT354-D1 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T354 phosphorylation is a key regulator of D1...
$ 350.00
NEW
Agonist-induced Threonine354 phosphorylation of the Dopamine Receptor 1
pS372/pS373-D1 (phospho-Dopamine Receptor 1...
Serine372/Serine373 (S372/S373) is a major phosphorylation site of the D1 receptor. The pS372/pS373-D1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S372/S373...
$ 350.00
NEW
Agonist-induced Threonine382/Threonine386 phosphorylation of the Dopamine Receptor 5
pT382/pT386-D5 (phospho-Dopamine Receptor 5...
Threonine382/Threonine386 (T382/T386) is a major phosphorylation site of the D5 receptor. The pT382/pT386-D5 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T382/T386...
$ 350.00

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi:10.1124/pr.110.002642. Epub 2011 Feb 8. Review. PubMed PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. Review. PubMed PMID: 25671228; PubMed Central PMCID: PMC4280963.

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Beaulieu JM, Gainetdinov RR. The physiology, signaling, and... read more »
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Dopamine Receptor Antibodies

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi:10.1124/pr.110.002642. Epub 2011 Feb 8. Review. PubMed PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. Review. PubMed PMID: 25671228; PubMed Central PMCID: PMC4280963.

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