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Galanin Receptor Antibodies

Galanin receptors are activated by the endogenous peptides galanin (GAL) and galanin-like peptide (GALP).The three galanin receptors, GAL1, GAL2 and GAL3, share a number of characteristics as members of the 7TM/GPCR family, but their functional coupling and signal transduction pathways are substantially different. GAL1 is widely expressed in the CNS with high expression in olfactory structures, amygdala, thalamus, hypothalamus, pons, medulla and spinal cord. GAL2 is abundant in the spinal trigeminal tract and the dorsal vagal complex. GAL3 is abundant in peripheral tissues. Galanin and galanin receptors have been linked to the regulation of a range of functions including metabolic and osmotic homeostasis, reproduction, nociception, arousal/sleep and cognition.

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Validation of the Galanin Receptor 1 in transfected HEK293 cells
GAL1 (non-phospho), Galanin Receptor 1 Antibody
The non-phospho-GAL1 receptor antibody is directed against the carboxyl-terminal tail of human GAL1. It can be used to detect total GAL1 receptors in Western blots independent of phosphorylation. The non-phospho-GAL1 antibody can also be...
$ 250.00
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pT340-GAL1 (phospho-Galanin Receptor 1 Antibody)
pT340-GAL1 (phospho-Galanin Receptor 1 Antibody)
Threonine340 (T340) is a major phosphorylation site of the GAL1 receptor. The pT340-GAL1 antibody detects phosphorylation in response to high-efficacy agonists. T340 phosphorylation is a key regulator of GAL1 desensitization, β-arrestin...
$ 350.00

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Lang R, Gundlach AL, Holmes FE, Hobson SA, Wynick D, Hökfelt T, Kofler B. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacol Rev. 2015;67(1):118-75. doi: 10.1124/pr.112.006536. PMID: 25428932.

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev. 2005 Jun;57(2):279-88. doi: 10.1124/pr.57.2.5. PMID: 15914470.

Gundlach AL, Ryan PJ. Galanin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4)

For more information on chemokine receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Lang R, Gundlach AL, Holmes FE, Hobson SA, Wynick D,... read more »
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Galanin Receptor Antibodies

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Lang R, Gundlach AL, Holmes FE, Hobson SA, Wynick D, Hökfelt T, Kofler B. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacol Rev. 2015;67(1):118-75. doi: 10.1124/pr.112.006536. PMID: 25428932.

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev. 2005 Jun;57(2):279-88. doi: 10.1124/pr.57.2.5. PMID: 15914470.

Gundlach AL, Ryan PJ. Galanin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4)

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