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Neuropeptide S Receptor Antibodies

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Agonist-induced Serine346/Serine349/Threonine352 phosphorylation of the NPS Receptor
pS346/pS349/pT352-NPSR (phospho-NPS Receptor...
Serine346/Serine349/threonine352 (S346/S349/T352) is major phosphorylation site of the NPS Receptor (NPSR). The pS346/pS349/pT352-NPRS antibody detects phosphorylation in response to agonists. S346/S349/T352 phosphorylation is likely to...
$ 350.00
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Validation of the Neuropeptide S Receptor in transfected HEK293 cells
NPSR (non-phospho), Neuropeptide S Receptor...
The NPSR antibody is directed against the distal end of the carboxyl-terminal tail of human Neuropeptide S Receptor. It can be used to detect total NPS receptors in Western blots independent of phosphorylation. The NPSR antibody can also...
$ 250.00

NPSR

The neuropeptide S receptor (NPSR) responds to the 20 amino-acid peptide neuropeptide S derived from a larger precursor protein. A comparison of the amino acid sequences of NPS has revealed that the peptide has been well conserved throughout evolution. Central administration of NPS was found to promote arousal and hyperlocomotion in mice and is able to suppress all stages of sleep in rats. The NPS receptor is coupled to Gq/G11 proteins and activation of phospholipase C. NPSR desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine346/serine349/threonine352 (pS346/pS349/TS352-NPSR). This nomenclature refers to the human NPS receptor. This phosphorylation motif is highly conserved across species. For more information on NPSR pharmacology please refer to the IUPHAR database. For further reading refer to:

Caló G, Civelli O, Reinscheid RK, Ruzza C. Neuropeptide S receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F44/2019.4.

The neuropeptide S receptor (NPSR) responds to the 20 amino-acid peptide neuropeptide S derived from a larger precursor protein. A comparison of the amino acid sequences of NPS has revealed... read more »
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Neuropeptide S Receptor Antibodies

NPSR

The neuropeptide S receptor (NPSR) responds to the 20 amino-acid peptide neuropeptide S derived from a larger precursor protein. A comparison of the amino acid sequences of NPS has revealed that the peptide has been well conserved throughout evolution. Central administration of NPS was found to promote arousal and hyperlocomotion in mice and is able to suppress all stages of sleep in rats. The NPS receptor is coupled to Gq/G11 proteins and activation of phospholipase C. NPSR desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine346/serine349/threonine352 (pS346/pS349/TS352-NPSR). This nomenclature refers to the human NPS receptor. This phosphorylation motif is highly conserved across species. For more information on NPSR pharmacology please refer to the IUPHAR database. For further reading refer to:

Caló G, Civelli O, Reinscheid RK, Ruzza C. Neuropeptide S receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F44/2019.4.

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