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Neurotensin Receptor 1 Antibodies

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NEW
 Agonist-induced Serine403/Serine404 phosphorylation of the Neurotensin Receptor 1
pS403/pS404-NTS1 (phospho-Neurotensin Receptor...
Serine403/Serine404 (S403/S404) is major phosphorylation site of the Neurotensin Receptor 1 (NTS1). The pS403/pS404-NTS1 antibody detects phosphorylation in response to agonists. S403/S404 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine401 phosphorylation of the Neurotensin Receptor
pS401-NTS1 (phospho-Neurotensin Receptor 1...
Serine401 (S401) is major phosphorylation site of the Neurotensin Receptor 1 (NTS1). The pS401-NTS1 antibody detects phosphorylation in response to agonists. S401 phosphorylation is likely to be involved in efficient ligand sequestration...
$ 350.00
Citations
Validation of the Neurotensin Receptor 1 in transfected HEK293 cells
NTS1 (non-phospho), Neurotensin Receptor 1...
The NTS1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Neurotensin Receptor 1. It can be used to detect total NTS1 receptors in Western blots independent of phosphorylation. The NTS1 antibody...
$ 250.00

NTS1

NTS1 is expressed mainly in the brain and intestine. In the rat brain, high levels of NTS1 are found in neurons of the diagonal band of Broca, medial septal nucleus, magnocellular preoptic area, suprachiasmatic nucleus, substantia nigra and ventral tegmental area. NTS1 is selectively expressed by central dopamine neurons and is clearly associated with mesolimbic and mesocortical systems. With regard to G protein-coupling, NTS1 is a Gq-preferring receptor in almost all systems examined. Activation of NTS1 is probably responsible for the observed effects of NT on cancer cell proliferation and food intake. However, the most convincing implication of NTS1 is related to the NT-dopamine interactions in the brain. Indeed, NT modulates dopamine transmisssion in the nigro-striatal and mesocorticolimbic pathways through NTS1, indicating that NT analogues specifically targeting this receptor might represent a new class of antipsychotic drugs. NTS1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine401 (pS401-NTS1) and serine403/serine404 (pS403/pS404-NTS1). This nomenclature refers to the human NTS1 receptor. For more information on NTS1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Mazella J, Sarret P, Vincent JP. Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F47/2019.4

NTS1 is expressed mainly in the brain and intestine. In the rat brain, high levels of NTS1 are found in neurons of the diagonal band of Broca, medial septal nucleus, magnocellular preoptic... read more »
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Neurotensin Receptor 1 Antibodies

NTS1

NTS1 is expressed mainly in the brain and intestine. In the rat brain, high levels of NTS1 are found in neurons of the diagonal band of Broca, medial septal nucleus, magnocellular preoptic area, suprachiasmatic nucleus, substantia nigra and ventral tegmental area. NTS1 is selectively expressed by central dopamine neurons and is clearly associated with mesolimbic and mesocortical systems. With regard to G protein-coupling, NTS1 is a Gq-preferring receptor in almost all systems examined. Activation of NTS1 is probably responsible for the observed effects of NT on cancer cell proliferation and food intake. However, the most convincing implication of NTS1 is related to the NT-dopamine interactions in the brain. Indeed, NT modulates dopamine transmisssion in the nigro-striatal and mesocorticolimbic pathways through NTS1, indicating that NT analogues specifically targeting this receptor might represent a new class of antipsychotic drugs. NTS1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine401 (pS401-NTS1) and serine403/serine404 (pS403/pS404-NTS1). This nomenclature refers to the human NTS1 receptor. For more information on NTS1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Mazella J, Sarret P, Vincent JP. Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F47/2019.4

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