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pS344/pS345-P2Y4 (phospho-P2Y Purinoceptor 4 Antibody)

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Agonist-induced Serine344/Serine345 phosphorylation of the P2Y Receptor
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  • 7TM0325B
  • 100 µl
  • Rabbit
Serine344/Serine345 (S344/S345) is a major phosphorylation site of the P2Y4 receptor.... more

Serine344/Serine345 (S344/S345) is a major phosphorylation site of the P2Y4 receptor. The pS344/pS345-P2Y4 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S344/S345 phosphorylation is a key regulator of P2Y4 desensitization, β-arrestin recruitment and internalization.

  Alternative Names P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4... more

 

Alternative Names P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4
IUPHAR Target ID  325
UniProt ID  P51582
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human P2Y4 around the phosphorylation site of Ser344/Ser345.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine344/Serine345 phosphorylation of the P2Y Purinoceptor 4.... more

Figure 1. Agonist-induced Serine344/Serine345 phosphorylation of the P2Y Purinoceptor 4. Upper panel, HEK293 cells stably expressing the P2Y Purinoceptor 4 (P2Y4) were either not exposed or exposed to 1 µM ATP (Adenosintriphosphate) or 0.1 μM PMA (Phorbol 12-Myristate 13-Acetate) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS344/pS345-P2Y4 antibody (7TM00325B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-P2Y4 antibody to confirm equal loading of the gel.


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