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EP2 Receptor Antibodies

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Agonist-induced Threonine342/Threonine344 phosphorylation of the EP2 Prostanoid Receptor
pT342/pT344-EP2 (phospho-EP2 Prostanoid...
Threonine342/Threonine344 (T342/T344) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pT342/pT344-EP2 antibody detects phosphorylation in response to agonists. T342/T344 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Threonine344/Serine345 phosphorylation of the EP2 Prostanoid Receptor
pT344/pS345-EP2 (phospho-EP2 Prostanoid...
Threonine344/Serine345 (T344/S345) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pT344/pS345-EP2 antibody detects phosphorylation in response to agonists. T344/S345 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Serine347/Threonine348phosphorylation of the EP2 Prostanoid Receptor
pS347/pT348-EP2 (phospho-EP2 Prostanoid...
Serine347/Threonine348 (S347/T348) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pS347/pT348-EP2 antibody detects phosphorylation in response to agonists. S347/T348 phosphorylation is likely to be involved in...
$ 350.00

EP2 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. EP2 receptors may be present on smooth muscle cells with high sensitivity to PGE2. Selective agonists based on the PGE2 structure exist and agonists with a non-prostanoid structure exist for EP2 receptors. Recently selective and potent EP2 receptor antagonists have emerged. EP2 receptors are regulated by phosphorylation of carboxyl-terminal threonine342/threonine344 (pT342/pT344-EP2), threonine344/serine345 (pT344/pS345-EP2) and serine347/threonine348 (pS347/pT348-EP2). This nomenclature refers to the human EP2 receptor. This phosphorylation motif is conserved across species but corresponds to pT344/pS345-EP2 and pS347/pT348-EP2 in mice and to pS345-EP2 and pS347/pT348-EP2 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

EP2 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. EP2 receptors may be present on smooth muscle cells with high sensitivity to PGE2. Selective agonists... read more »
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EP2 Receptor Antibodies

EP2 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. EP2 receptors may be present on smooth muscle cells with high sensitivity to PGE2. Selective agonists based on the PGE2 structure exist and agonists with a non-prostanoid structure exist for EP2 receptors. Recently selective and potent EP2 receptor antagonists have emerged. EP2 receptors are regulated by phosphorylation of carboxyl-terminal threonine342/threonine344 (pT342/pT344-EP2), threonine344/serine345 (pT344/pS345-EP2) and serine347/threonine348 (pS347/pT348-EP2). This nomenclature refers to the human EP2 receptor. This phosphorylation motif is conserved across species but corresponds to pT344/pS345-EP2 and pS347/pT348-EP2 in mice and to pS345-EP2 and pS347/pT348-EP2 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

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