EP4 Receptor Antibodies
EP4 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. The functional selectivity of natural and synthetic EP4 receptor agonists has been assessed in terms of cAMP production and β-arrestin recruitment. Currently there is interest in selective EP4 receptor antagonists as anti-inflammatory agents.EP4 receptors are regulated by phosphorylation of carboxyl-terminal serine364/serine366 (pS364/pS366-EP4), threonine369/serine370 (pT369/pS370-EP4) and serine374/serine377 (pS374/pS377-EP4). This nomenclature refers to the human EP4 receptor. This phosphorylation motif is conserved across species but corresponds to pS392/pS394-EP4, pT397/pS398-EP4 and pS402/pS405-EP4 in mice and pS367/pS369-EP4, pT371/pS372-EP4 and pS377/pS380-EP4 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:
Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.
Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.