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Somatostatin Receptor Antibodies

Somatostatin receptors are activated by somatotropin-release inhibiting factor (SRIF) that exerts potent inhibitory actions on hormone secretion and neuronal excitability. The somatostatin receptor family consists of five members designated somatostatin receptors 1-5 (SST1-SST5). SST2 is the pharmacological target for octreotide (Sandostatin) which is the first line medical treatment for growth hormone (GH)-producing adenomas (acromegaly) and gastrointestinal neuroendocrine tumors (NET). SST5 is the primary pharmacological target for pasireotide (Signifor) which is the first line medical treatment for adrenocorticotropic hormone (ACTH)-producing adenomas (Cushing’s disease). In addition, SST2 is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions of human tumors.

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Citations
KO-Validated
Western blot analysis of Somatostatin Receptor 2 in mouse brain in vivo.
SST2 (non-phospho), Somatostatin Receptor 2...
The non-phospho-SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human SST2. It detects selectively the canonical form of SST2 (also referred to as SST2A) and not the putative...
$ 350.00
Citations
Agonist-induced Threonine348 phosphorylation of the Somatostatin Receptor 3.
pT348-SST3 (phospho-Somatostatin Receptor 3...
Threonine348 (T348) is a major phosphorylation site of the somatostatin receptor 3 (SST3). The pT348-SST3 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T348 phosphorylation...
$ 350.00
Citations
Agonist-induced Serine337/Threonine341 phosphorylation of the Somatostatin Receptor 3.
pS337/pT341-SST3 (phospho-Somatostatin Receptor...
Serine337/Threonine341 (S337/T341) is a major phosphorylation site of the somatostatin receptor 3 (SST3). The pS337/pT341-SST3 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation....
$ 350.00
Citations
Agonist-induced Threonine333 phosphorylation of the Somatostatin Receptor 5.
pT333-SST5 (phospho-Somatostatin Receptor 5...
Threonine333 (T333) is a major phosphorylation site of the human somatostatin receptor 5 (SST5). The pT333-SST5 antibody detects phosphorylation in response to high-efficacy agonists such as pasireotide but not after activation of PKC....
$ 350.00
Citations
KO-Validated
Validation of the Somatostatin Receptor 5 in transfected HEK293 cells.
SST5 (non-phospho), Somatostatin Receptor 5...
The non-phospho-SST5 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human SST5. In can be used to detect total SST5 receptors in Western blots independent of phosphorylation. The non-phospho-SST5...
$ 350.00
Citations
Validation of the Somatostatin Receptor 3 in transfected HEK293 cells.
SST3 (non-phospho), Somatostatin Receptor 3...
The non-phospho-SST3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human SST3. In can be used to detect total SST3 receptors in Western blots independent of phosphorylation. The non-phospho-SST3...
$ 350.00
Citations
Agonist-induced Serine341/Serine343 phosphorylation of the Somatostatin Receptor 2.
pS341/pS343-SST2 (phospho-Somatostatin Receptor...
Serine341/Serine343 (S341/S343) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pS341/pS343-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy...
$ 350.00
Citations
Agonist-induced Threonine353/Threonine354 phosphorylation of the Somatostatin Receptor 2.
pT353/pT354-SST2 (phospho-Somatostatin Receptor...
Threonine353/Threonine354 (T353/T354) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pT353/pT354-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy...
$ 350.00
Citations
Agonist-induced Threonine356/Threonine359 phosphorylation of the Somatostatin Receptor 2.
pT356/pT359-SST2 (phospho-Somatostatin Receptor...
Threonine356/Threonine359 (T356/T359) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pT356/pT359-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy...
$ 350.00

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to: Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp... read more »
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Somatostatin Receptor Antibodies

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

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