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Tachykinin Receptor Antibodies

Tachykinin receptors are activated by the endogenous peptides substance P (SP), neurokinin A (NKA), neurokinin B (NKB). There are three tachykinin receptors; NK1, NK2, and NK3, and each has a preferred ligand; SP, NKA, and NKB, respectively. The term tachykinin was originally used to identify SP because it produced spasmodic effects in various intestinal smooth muscle cells. Tachy is Greek for rapid and Kinin is Greek for set in motion. Together these terms described the rapid contraction of smooth muscle treated with SP. NK1 and NK3 are widely distributed in the central nervous system, while NK2 is localized in the smooth muscle of the gastrointestinal, respiratory, and urinary tracts and some discrete regions of the CNS such as the prefrontal cortex and the hippocampus. Antagonists such as aprepitant and fosaprepitant were approved for the prevention of nausea and vomiting associated with cancer chemotherapy.

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NK1 (non-phospho), Neurokinin Receptor 1/Substance P Receptor Antibody
NK1 (non-phospho), Neurokinin Receptor...
The NK1 antibody is directed against the distal end of the carboxyl-terminal tail of human Neurokinin Receptor 1 (also called Substance P Receptor). It detects selectively the canonical full-length NK1 Tachykinin Receptor. It can be used...
$ 350.00
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pT344/pS347-NK1 (phospho-Neurokinin Receptor 1 Antibody)
pT344/pS347-NK1 (phospho-Neurokinin Receptor 1...
Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor. The pT344/pS347-NK1 antibody detects phosphorylation in response to high-efficacy agonists. T344/S347 phosphorylation is a key regulator of NK1...
$ 350.00

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas SD, Fong TM, Heyward CY, Leeman SE, Remeshwar P. Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on chemokine receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas... read more »
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Tachykinin Receptor Antibodies

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas SD, Fong TM, Heyward CY, Leeman SE, Remeshwar P. Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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