Immuno-Grade GPR12 Receptor Antibodies

GPR12 (G Protein-Coupled Receptor 12) is an orphan GPCR with constitutive activity that leads to increased intracellular cAMP levels via Gs protein coupling. It is structurally related to cannabinoid and sphingosine-1-phosphate (S1P) receptors and has been suggested to interact with lipid ligands, although a definitive endogenous ligand has not been confirmed. GPR12 is mainly expressed in the central nervous system, particularly in the brain regions involved in emotional regulation and neurodevelopment, such as the hippocampus and cortex. It is also detected in peripheral tissues including the reproductive system and certain cancer cell lines. GPR12 is under investigation as a potential pharmacological target due to its roles in neurodevelopment, emotional behavior, and cell proliferation. Emerging evidence suggests involvement in neurological disorders and cancer progression. For more information on GPR12 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.