Immuno-Grade GPR15 Receptor Antibodies

GPR15 (G Protein-Coupled Receptor 15), also known as BOB (B cell orphan receptor), is a GPCR that is primarily involved in immune cell trafficking and inflammatory responses. It binds to ligands such as the chemokine CCL5 (RANTES) and CCL19, and it plays a role in the migration and activation of immune cells, including T cells and B cells. GPR15 is primarily expressed in immune cells, particularly in T lymphocytes, including regulatory T cells (Tregs), as well as in some B cells, monocytes, and certain epithelial cells. It is also found in the gastrointestinal tract, where it is involved in the regulation of gut-associated immune responses. GPR15 is being explored as a potential pharmacological target in inflammatory diseases, autoimmune disorders, and conditions involving immune cell dysregulation, such as inflammatory bowel disease (IBD) and multiple sclerosis. Its role in immune cell migration and activation suggests it could be targeted to modulate immune responses, though research on selective GPR15 modulators is still in early stages. For more information on GPR15 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.