Neuropeptide S Receptor Antibodies
The neuropeptide S receptor (NPSR) responds to the 20 amino-acid peptide neuropeptide S derived from a larger precursor protein. A comparison of the amino acid sequences of NPS has revealed that the peptide has been well conserved throughout evolution. Central administration of NPS was found to promote arousal and hyperlocomotion in mice and is able to suppress all stages of sleep in rats. The NPS receptor is coupled to Gq/G11 proteins and activation of phospholipase C. NPSR desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine346/serine349/threonine352 (pS346/pS349/TS352-NPSR). This nomenclature refers to the human NPS receptor. This phosphorylation motif is highly conserved across species. For more information on NPSR pharmacology please refer to the IUPHAR database. For further reading refer to:
Caló G, Civelli O, Reinscheid RK, Ruzza C. Neuropeptide S receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F44/2019.4.