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pT362/pS363-NPY1 (phospho-Neuropeptide Y Receptor 1 Antibody)

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Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor 1
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  • 7TM0305B
  • 100 µl
  • Rabbit
Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y... more

Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y Receptor 1. The pT362/pS363-NPY1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T362/S363 phosphorylation is primarily mediated by GRKs and is a key regulator of NPY1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names Y1, NPY 1 receptor, neuropeptide Y receptor type 1... more

 

Alternative Names Y1, NPY 1 receptor, neuropeptide Y receptor type 1
IUPHAR Target ID  305
UniProt ID  P25929
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human NPY1 around the phosphorylation site of Thr362/Ser363.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor... more

Figure 1. Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor 1. Upper panel, HEK293 cells stably expressing the NPY1-Receptor (NPY1) were either not exposed or exposed to 1 µM of  NPY1 receptor agonist Neuropeptide Y for 30 minutes. Cells were lysed and immunoblotted with the anti-pT362/pS363-NPY1 antibody (7TM0305B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-NPY1 antibody to confirm equal loading of the gel.

 

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