pT342/pS343/pT345-S1P2 (phospho-Sphingosine 1-Phosphate Receptor 2 Antibody)

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Order number: 7TM0276B
Content: 100 µl
Host: Rabbit

Threonine342Serine343/Threonine345 (T342/S343/T345) is major phosphorylation site of... more

Threonine342Serine343/Threonine345 (T342/S343/T345) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 2 (S1P2). The pT342/pS343/pT345-S1P2 antibody detects phosphorylation in response to agonists. T342/S343/T345 phosphorylation is likely to be involved in efficient ligand sequestration by S1P2.

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Alternative Names S1P Receptor 2, Edg5, endothelial differentiation G... more

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Alternative Names	S1P Receptor 2, Edg5, endothelial differentiation G protein-coupled receptor 5
IUPHAR Target ID	276
UniProt ID	O95136
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human S1P2 around the phosphorylation site of Thr342/Ser343/Thr345.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine342/Serine343/Threonine345 phosphorylation of the... more

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Figure 1. Agonist-induced Threonine342/Serine343/Threonine345 phosphorylation of the Sphingosine 1-Phosphate Receptor 2. Upper panel, HEK293 cells stably expressing the S1P2-Receptor (S1P2) were either not exposed or exposed to 1 µM of S1P2-Receptor agonists S1P for 30 minutes. Cells were lysed and immunoblotted with the anti-pT342/pS343/pT345-S1P2 antibody (7TM00276B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-S1P2 antibody to confirm equal loading of the gel.

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