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Bombesin Receptor Antibodies

Mammalian bombesin receptors (BB) comprise 3 subtypes: BB1, BB2, BB3. BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-releasing peptide (GRP), and GRP-(18-27). Bombesin is a tetra-decapeptide, originally derived from amphibians. The three BB receptor subtypes couple primarily to the Gq/11 and G12/13 family of G proteins. Activation of BB1 and BB2 receptors causes a wide range of physiological actions including the stimulation of cell growth, smooth-muscle contraction, feeding behavior, regulation of circadian rhythm, body temperature control and mediation of pruritus. A physiological role for the BB3 receptor has yet to be fully defined although recently studies suggest an important role metabolic homeostasis and obesity. BB receptors are one of the most frequently overexpressed GPCRs in cancer.

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pT363/pT364-BB3 Phosphorylation Assay Kit
pT363/pT364-BB3 Phosphorylation Assay Kit
The pT363/pT364-BB3 Phosphorylation Assay Kit allows determination of BB3 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 * $ 600.00 *
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OD signals in pT360/pS361-BB3
pT360/pS361-BB3 Phosphorylation Assay Kit
The pT360/pS361-BB3 Phosphorylation Assay Kit allows determination of BB3 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 * $ 600.00 *
Details

For more information on bombesin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab. 2016 Sep;27(9):603-605. doi: 10.1016/j.tem.2016.03.003. Epub 2016 Apr 4. PMID: 27055378; PMCID: PMC4992652.

For more information on bombesin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Jensen RT, Battey JF, Spindel ER, Benya RV. International... read more »
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Bombesin Receptor Antibodies

For more information on bombesin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab. 2016 Sep;27(9):603-605. doi: 10.1016/j.tem.2016.03.003. Epub 2016 Apr 4. PMID: 27055378; PMCID: PMC4992652.

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