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Angiotensin Receptor Antibodies

The actions of angiotensin II (Ang II) are mediated by two types of mammalian receptors designated AT1 for angiotensin type 1 receptor and AT2 for angiotensin type 2 receptor. AT1 and AT2 receptors share around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. The human genome contains single genes for AT1 and AT2. In rodents and zebra fish two genes encoding subtypes AT1a and AT1b exist. Most actions of Ang II, such as maintainance of blood pressure and glomerular filtration rate in response to extracellular volume depletion are mediated through the AT1 receptor. The AT2 receptor mediated effects in various tissues indeed may critically require local conversion of Ang II to Ang III through the involvement of resident aminopeptidase in specific tissues such as kidney and brain. Losartan, candesartan, telmisartan, etc. are clinically used AT1 receptor blockers.

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Agonist-induced Serine335/Threonine336 phosphorylation of the Angiotensin Receptor 1
pS335/pT336-AT1 (phospho-Angiotensin Receptor 1...
Serine335/Threonine336 (S335/T336) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS335/pT336-AT1 antibody detects phosphorylation in response to agonists. S335/T336 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine346/Serine347 phosphorylation of the Angiotensin Receptor 1
pS346/pS347-AT1 (phospho-Angiotensin Receptor 1...
Serine346/Serine347 (S346/S347) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS346/pS347-AT1 antibody detects phosphorylation in response to agonists. S346/S347 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine331/Threonine332 phosphorylation of the Angiotensin Receptor 1
pS331/pT332-AT1 (phospho-Angiotensin Receptor 1...
Serine331/Threonine332 (S331/T332) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS331/pT332-AT1 antibody detects phosphorylation in response to agonists. S331/T332 phosphorylation is likely to be involved in...
$ 350.00
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Validation of the Angiotensin Receptor 1 in transfected HEK293 cells
AT1 (non-phospho-Angiotensin Receptor 1 Antibody)
The non-phospho-AT1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Angiotensin Receptor 1 (AT1). It can be used to detect total AT1 receptors in Western blots independent of phosphorylation....
$ 250.00

For more information on angiotensin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. PMID: 10977869.

Alexander W, Bernstein KE, Catt KJ, de Gasparo M, Dhanachandra Singh K, Eguchi S, Escher E, Goodfriend TL, Horiuchi M, Hunyady L, Husain A, Inagami T, Karnik S, Kemp J, Thomas WG, Timmermans PBMWM, Tirupula K, Unal H, Unger T, Vanderheyden P. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on angiotensin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T.... read more »
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Angiotensin Receptor Antibodies

For more information on angiotensin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. PMID: 10977869.

Alexander W, Bernstein KE, Catt KJ, de Gasparo M, Dhanachandra Singh K, Eguchi S, Escher E, Goodfriend TL, Horiuchi M, Hunyady L, Husain A, Inagami T, Karnik S, Kemp J, Thomas WG, Timmermans PBMWM, Tirupula K, Unal H, Unger T, Vanderheyden P. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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