Cholecystokinin Receptor 2 Antibodies
The human cholcystokinin receptor 2 (CCK2) is activated by endogenous gastrin and cholecystokinin peptides. CCK2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine427/serine429 (pT427/pS429-CCK2) and serine437/threonine439 (pS437/pT439-CCK2). This nomenclature refers to the human CCK2. This phosphorylation motif is conserved across species but corresponds to pT433/pS435-CCK2 and pS443/pT445-CCK2 in mice and pT432/pS434-CCK2 and pS442/pT444-CCK2 in rats. For more information on CCK2 pharmacology please refer to the IUPHAR database. For further reading refer to:
Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev. 1999 Dec;51(4):745-81. Erratum in: Pharmacol Rev 2000 Mar;52(1):177. PMID: 10581329.
Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev. 2006 Jul;86(3):805-47. doi: 10.1152/physrev.00014.2005. PMID: 16816139.