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Tachykinin Receptor Antibodies

Tachykinin receptors are activated by the endogenous peptides substance P (SP), neurokinin A (NKA), neurokinin B (NKB). There are three tachykinin receptors; NK1, NK2, and NK3, and each has a preferred ligand; SP, NKA, and NKB, respectively. The term tachykinin was originally used to identify SP because it produced spasmodic effects in various intestinal smooth muscle cells. Tachy is Greek for rapid and Kinin is Greek for set in motion. Together these terms described the rapid contraction of smooth muscle treated with SP. NK1 and NK3 are widely distributed in the central nervous system, while NK2 is localized in the smooth muscle of the gastrointestinal, respiratory, and urinary tracts and some discrete regions of the CNS such as the prefrontal cortex and the hippocampus. Antagonists such as aprepitant and fosaprepitant were approved for the prevention of nausea and vomiting associated with cancer chemotherapy.

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Agonist-induced Threonine402/Threonine404 phosphorylation of the NK 3 Receptor.
pT402/pT404-NK3 (phospho-Tachykinin Receptor 3...
Threonine402/Threonine404 (T402/T404) is a major phosphorylation site of the NK3 receptor. The pT402/pT404-NK3 antibody detects phosphorylation in response to high-efficacy agonists. T402/T404 phosphorylation is a key regulator of NK3...
$ 350.00 *
NEW
Agonist-induced Serine398/Serine399 phosphorylation of the NK 3 Recept
pS398/pS399-NK3 (phospho-Tachykinin Receptor 3...
Serine398/Serine399 (S398/S399) is major phosphorylation site of the Tachykinin Receptor 3 (NK3). The pS398/pS399-NK3 antibody detects phosphorylation in response to agonists. S398/S399 phosphorylation is likely to be involved in...
$ 350.00 *
NEW
Agonist-induced Threonine389/Threonine390 phosphorylation of the NK3 Receptor3.
pT389/pT390-NK3 (phospho-Tachykinin Receptor 3...
Threonine389/Threonine390 (T389/T390) is a major phosphorylation site of the NK3 receptor. The pT389/pT390-NK3 antibody detects phosphorylation in response to high-efficacy agonists. T389/T390 phosphorylation is a key regulator of NK3...
$ 350.00 *
NEW
Agonist-induced Threonine356/Threonine357 phosphorylation of NK1 Receptor
pT356/pT357-NK1 (phospho-Tachykinin Receptor 1...
Threonine356/Threonine357 (T356/T357) is a major phosphorylation site of the NK1 receptor. The pT356/pT357-NK1 antibody detects phosphorylation in response to high-efficacy agonists. T356/T357 phosphorylation is a key regulator of NK1...
$ 350.00 *
NEW
Agonist-induced Serine338/Threonine339 phosphorylation of NK1 Receptor
pS338/pT339-NK1 (phospho-Tachykinin Receptor 1...
Serine338/Threonine339 (S338/T339) is a major phosphorylation site of the NK1 receptor. The pS338/pT339-NK1 antibody detects phosphorylation in response to high-efficacy agonists. S338/T339 phosphorylation is a key regulator of NK1...
$ 350.00 *
NEW
pT344/pS347-NK1 (phospho-Tachykinin Receptor 1 Antibody)
pT344/pS347-NK1 (phospho-Tachykinin Receptor 1...
Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor. The pT344/pS347-NK1 antibody detects phosphorylation in response to high-efficacy agonists. T344/S347 phosphorylation is a key regulator of NK1...
$ 350.00 *
Citations
Validation of the Tachykinin Receptor 1 in transfected HEK293 cells
NK1 (non-phospho), Tachykinin Receptor 1 Antibody
The NK1 antibody is directed against the distal end of the carboxyl-terminal tail of human Tachykinin Receptor 1 (also called Substance P Receptor). It detects selectively the canonical full-length NK1 Tachykinin Receptor. It can be used...
$ 350.00 *

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas SD, Fong TM, Heyward CY, Leeman SE, Remeshwar P. Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on chemokine receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas... read more »
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Tachykinin Receptor Antibodies

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas SD, Fong TM, Heyward CY, Leeman SE, Remeshwar P. Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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