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Immuno-Grade Corticotropin-Releasing Factor Receptor 1 Antibodies

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Citations
KO-Validated
Immunohistochemical identification of Corticotropin-Releasing Factor Receptor 1 in anterior pituitary
CRF1 (IHC-grade), Corticotropin-Releasing...
The CRF1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human CRF1. It can be used to detect total CRF1 receptors in Western blots independent of phosphorylation. The CRF1 antibody can also be used...
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The CRF1 receptor is widely expressed in the central nervous system with high levels of expression in cortex, cerebellum, hippocampus, basolateral amygdala, bed nucleus of the stria terminalis, olfactory bulb and anterior pituitary. In the periphery, CRF1 receptor is expressed at low levels in the skin, ovary, testis and adrenal gland. CRF, urocortin 1 (UCN1) and urotensin I all bind with high affinity to the mammalian CRF1 receptor and activate the cyclic AMP signaling pathway. In contrast, UCN2 and UCN3 do not bind to or activate CRF1 receptors. Therefore, CRF and urocortin 1 can be classified as the endogenous ligands for mammalian CRF1 receptors. 

The CRF1 receptor is widely expressed in the central nervous system with high levels of expression in cortex, cerebellum, hippocampus, basolateral amygdala, bed nucleus of the stria terminalis,... read more »
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Immuno-Grade Corticotropin-Releasing Factor Receptor 1 Antibodies

The CRF1 receptor is widely expressed in the central nervous system with high levels of expression in cortex, cerebellum, hippocampus, basolateral amygdala, bed nucleus of the stria terminalis, olfactory bulb and anterior pituitary. In the periphery, CRF1 receptor is expressed at low levels in the skin, ovary, testis and adrenal gland. CRF, urocortin 1 (UCN1) and urotensin I all bind with high affinity to the mammalian CRF1 receptor and activate the cyclic AMP signaling pathway. In contrast, UCN2 and UCN3 do not bind to or activate CRF1 receptors. Therefore, CRF and urocortin 1 can be classified as the endogenous ligands for mammalian CRF1 receptors. 

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