Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

Free Fatty Acid Receptor Antibodies

Free fatty acid receptors (FFA) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids including myristic acid, palmitic acid, oleic acid, linoleic acid and arachidonic acid activate FFA1 and FFA4 receptors, while short chain fatty acids including acetic acid, propanoic acid, butyric acid and pentanoic acid activate FFA2 and FFA3 receptors. In addition, GPR84 is putatively activated by medium-chain fatty acids. Long-chain fatty acids are thought to reach levels of 0.01-10 μM in the circulation, mainly being products of dietary intake, adipose recycling and hepatic turnover of neutral fats. Short chain fatty acids are generated during fermentation of resistant starches and indigestible fiber by anaerobic gut flora and can reach millimolar concentrations in the hind-gut. Short chain fatty acids can also be generated as metabolic byproducts of anaerobic bacteria and following alcohol ingestion. The concentration of total short chain fatty acids in human peripheral blood is 50-100 μM and 300-450 μM in portal blood.  It is possible that, rather than being redundant, that receptor tissue distribution combined with local fatty acid levels and their carbon chain-lengths and degree of saturation will determine the physiological role of the receptors. The role of FFA1 is best understood due to the phenotyping of transgenic mice and identification of selective small-molecule agonists and an antagonist. With the central role that fatty acids play in metabolism and other physiological functions including regulation of the immune response, the FFA receptor family currently provide a key focus for development of novel therapeutic agents.

Close filters
No results were found for the filter!
NEW
Immunohistochemical Identification of Threonine306/Threonine310 phosphorylation of the FFA Receptor 2 in mouse neuroendocrine cells and peyer's patches.
pT306/pT310-FFA2 (IHC grade phospho-FFA2 Antibody)
Threonine306/Threonine310 (T306/T310) is major phosphorylation site of the FFA 2 Receptor (FFA2). The pT306/pT310-FFA2 antibody detects phosphorylation in response to agonists. T306/T310 phosphorylation is likely to be involved in...
$ 500.00 *
NEW
Immunohistochemical Identification of Serine296/Serine297 phosphorylation of the FFA Receptor 2 in mouse white adipose tissue and peyer's patches.
pS296/pS297-FFA2 (IHC-grade phospho-FFA2 Antibody)
Serine296/Serine297 (S296/S297) is major phosphorylation site of the FFA Receptor 2 (FFA2). The pS296/pS297-FFA2 antibody detects constitutive phosphorylation of FFA2.
$ 500.00 *

For more information on free fatty acid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

For more information on free fatty acid receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Stoddart LA, Smith NJ, Milligan G. International... read more »
Close window
Free Fatty Acid Receptor Antibodies

For more information on free fatty acid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Recently viewed