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C5a1 Receptor Phosphorylation Assays

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OD signals in pT342-C5a1 Phosphorylation Assay
pT342-C5a1 Phosphorylation Assay Kit
The pT342-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
50
NEW
OD signals in pS338/pT339-C5a1 Phosphorylation Assay
pS338/pT339-C5a1 Phosphorylation Assay Kit
The pS338/pT339-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
50
NEW
OD signals in pS332/pS334-C5a1 Phosphorylation Assay
pS332/pS334-C5a1 Phosphorylation Assay Kit
The pS332/pS334-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
50
NEW
OD signals in pT324pS327-C5a1 Phosphorylation Assay
pT324/pS327-C5a1 Phosphorylation Assay Kit
The pT324/pS327-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *

C5a1qPBs5imy45i29

C5a1 is the specific receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production in macrophages and other immune cells. The development of potent and selective antagonists has been proposed as a strategy for new anti-inflammatory compounds for diseases in which damage by neutrophils plays a key role. C5a1 desensitization, β-arrestin recruitment and internalization is regulated by phosphorylation of carboxyl-terminal threonine324/serine327 (pT324/pS327-C5a1), serine332/serine334 (pS332/pS334-C5a1) threonine336 (pT336-C5a1), threonine338/threonine339 (pT338/pS339-C5a1) and threonine342 (pT342-C5a1) residues. This nomenclature refers to the human C5a1 receptor. This phosphorylation motif is conserved across species but corresponds to pS325/pS328-C5a1 and pS333/pS335-C5a1 in mice and pS325/pS328-C5a1 and pS334/pS336-C5a1 in rats. T324/S327 are also subject to phosphorylation by PKC. For more information on C5a1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

Nürge B, Schulz AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A. Immunohistochemical identification of complement peptide C5a receptor 1 (C5aR1) in non-neoplastic and neoplastic human tissues. PLoS One. 2021 Feb 19;16(2):e0246939. doi: 10.1371/journal.pone.0246939. PMID: 33606748; PMCID: PMC7894821.

C5a1 is the specific receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release... read more »
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C5a1 Receptor Phosphorylation Assays

C5a1qPBs5imy45i29

C5a1 is the specific receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production in macrophages and other immune cells. The development of potent and selective antagonists has been proposed as a strategy for new anti-inflammatory compounds for diseases in which damage by neutrophils plays a key role. C5a1 desensitization, β-arrestin recruitment and internalization is regulated by phosphorylation of carboxyl-terminal threonine324/serine327 (pT324/pS327-C5a1), serine332/serine334 (pS332/pS334-C5a1) threonine336 (pT336-C5a1), threonine338/threonine339 (pT338/pS339-C5a1) and threonine342 (pT342-C5a1) residues. This nomenclature refers to the human C5a1 receptor. This phosphorylation motif is conserved across species but corresponds to pS325/pS328-C5a1 and pS333/pS335-C5a1 in mice and pS325/pS328-C5a1 and pS334/pS336-C5a1 in rats. T324/S327 are also subject to phosphorylation by PKC. For more information on C5a1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

Nürge B, Schulz AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A. Immunohistochemical identification of complement peptide C5a receptor 1 (C5aR1) in non-neoplastic and neoplastic human tissues. PLoS One. 2021 Feb 19;16(2):e0246939. doi: 10.1371/journal.pone.0246939. PMID: 33606748; PMCID: PMC7894821.

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