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M3 Muscarinic Acetylcholine Receptors Antibodies

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Agonist-induced Serine332/Serine333/Serine334 phosphorylation of the M3 Muscarinic Acetycholine Receptor.
pS332/pS333/pS334-M3 (phospho-M3 Muscarinic...
Serine332/Serine333/Serine334 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS332/pS333/pS334-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation....
$ 350.00
NEW
Agonist-induced Serine359/Threonine361 phosphorylation of the M3 Muscarinic Acetylcholine Receptor
pS359/pT361-M3 (phospho-M3 Muscarinic...
Serine359/Threonine361 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS359/pT361-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S359/T361...
$ 350.00
NEW
Agonist-induced Serine385/Serine386 phosphorylation of the M3 Muscarinic Acetylcholine Receptor
pS385/pS386-M3 (phospho-M3 Muscarinic...
Serine385/Serine386 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS385/pS386-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S385/S386...
$ 350.00
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Validation of the M3 Muscarinic Acetylcholine Receptor in transfected HEK293 cells
M3 (non-phospho-M3 Muscarinic Acetylcholine...
The non-phospho-M3 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human M3 Muscarinic Acetylcholine Receptor (M3). It can be used to detect total M3 receptors in Western blots independent of...
$ 250.00

 

Functionally, M3-muscarinic receptors preferentially couple to Gq/11 proteins. Contraction of smooth muscle, particularly of airway, ileum, iris and bladder, are considered classical muscarinic responses mediated primarily by M3 receptors expressed on the smooth muscle cells. Exocrine secretion, particularly of saliva, and as shown more recently, insulin secretion is also primarily mediated by M3 receptors. M3 receptors are considered drug targets for type 2 diabetes, obesity, and chronic obstructive pulmonary disease. M3 receptor activity is regulated by phosphorylation of serine332/serine333/serine334, serine359/threonine361 and serine385/serine386 in the 3rd intracellular loop. This nomenclature refers to the human M3 but is highly conserved in mice and rats. For more information on M3 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998 Jun;50(2):279-90. PMID: 9647869.

Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007 Sep;6(9):721-33. doi: 10.1038/nrd2379. PMID: 17762886.

Birdsall NJM, Bradley S, Brown DA, Buckley NJ, Challiss RJ, Christopoulos A, Eglen RM, Ehlert F, Felder CC, Hammer R, Kilbinger HJ, Lambrecht G, Langmead C, Mitchelson F, Mutschler E, Nathanson NM, Schwarz RD, Thal D, Tobin AB, Valant C, Wess J. Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(3).

  Functionally, M3-muscarinic receptors preferentially couple to Gq/11 proteins. Contraction of smooth muscle, particularly of airway, ileum, iris and bladder, are considered classical... read more »
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M3 Muscarinic Acetylcholine Receptors Antibodies

 

Functionally, M3-muscarinic receptors preferentially couple to Gq/11 proteins. Contraction of smooth muscle, particularly of airway, ileum, iris and bladder, are considered classical muscarinic responses mediated primarily by M3 receptors expressed on the smooth muscle cells. Exocrine secretion, particularly of saliva, and as shown more recently, insulin secretion is also primarily mediated by M3 receptors. M3 receptors are considered drug targets for type 2 diabetes, obesity, and chronic obstructive pulmonary disease. M3 receptor activity is regulated by phosphorylation of serine332/serine333/serine334, serine359/threonine361 and serine385/serine386 in the 3rd intracellular loop. This nomenclature refers to the human M3 but is highly conserved in mice and rats. For more information on M3 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998 Jun;50(2):279-90. PMID: 9647869.

Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007 Sep;6(9):721-33. doi: 10.1038/nrd2379. PMID: 17762886.

Birdsall NJM, Bradley S, Brown DA, Buckley NJ, Challiss RJ, Christopoulos A, Eglen RM, Ehlert F, Felder CC, Hammer R, Kilbinger HJ, Lambrecht G, Langmead C, Mitchelson F, Mutschler E, Nathanson NM, Schwarz RD, Thal D, Tobin AB, Valant C, Wess J. Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(3).

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