Galanin Receptor 2 Antibodies

GAL2 signals via phospholipase C activation, which increases insoitol phosphate hydrolysis, mediating the release of Ca2+ into the cytoplasm from intracellular stores and opening Ca2+-dependent chloride channels. These GAL2 receptor-mediated intracellular effects are not affected by pertussis toxin. GAL2 is more broadly expressed than GAL1. Mice with GAL2 receptor knockout exhibit a more persistent depressive-like phenotype in the learned helplessness paradigm and increased immobility in the tail suspension test. GAL2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine329/serine331/serine333 (pT329/pS331-GAL2 and pT331/pS333-GAL2) and serine339/serine340 (pS339/pS340-GAL2). This nomenclature refers to the human GAL2 receptor. For more information on GAL2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Lang R, Gundlach AL, Holmes FE, Hobson SA, Wynick D, Hökfelt T, Kofler B. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacol Rev. 2015;67(1):118-75. doi: 10.1124/pr.112.006536. PMID: 25428932.

Gundlach AL, Ryan PJ. Galanin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).