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Free Fatty Acid Receptor 4 Antibodies

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Immunohistochemical identification of FFA4 Receptor in human spleen
FFA4 (IHC-grade), FFA4 Receptor Antibody
The FFA4 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA4. It can be used to detect total FFA4 receptors in Western blots independent of phosphorylation. The FFA4 antibody can also be used...
$ 350.00

FFA4 is a receptor for long-chain fatty acids with a major role in adipogenesis, energy metabolism and inflammation. FFA4 induces differentiation of brown and beige adipocytes and contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Signals via G-protein and beta-arrestin pathways. Long-chain fatty acid sensing initiates activation of phosphoinositidase C-linked Gq/G11 proteins. FFA4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-FFA4) and threonine349/serine350 (pT349/pS350-FFA4). This nomenclature refers to the human FFA4 receptor. For more information on FFA4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

FFA4 is a receptor for long-chain fatty acids with a major role in adipogenesis, energy metabolism and inflammation. FFA4 induces differentiation of brown and beige adipocytes and contributes to... read more »
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Free Fatty Acid Receptor 4 Antibodies

FFA4 is a receptor for long-chain fatty acids with a major role in adipogenesis, energy metabolism and inflammation. FFA4 induces differentiation of brown and beige adipocytes and contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Signals via G-protein and beta-arrestin pathways. Long-chain fatty acid sensing initiates activation of phosphoinositidase C-linked Gq/G11 proteins. FFA4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-FFA4) and threonine349/serine350 (pT349/pS350-FFA4). This nomenclature refers to the human FFA4 receptor. For more information on FFA4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

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