Formylpeptide Receptor 3 Antibodies

Formyl peptide receptor 3 (FPR3), formerly known as FPRL2 and encoded by FPR3, is a class A G protein-coupled receptor expressed primarily in monocytes and dendritic cells. Its best-characterized endogenous agonist is F2L, a 21-amino-acid N-acetylated peptide generated by cathepsin D cleavage of heme-binding protein 1. FPR3 responds poorly to fMLF, the prototypical bacterial N-formyl peptide agonist of FPR1. F2L activates FPR3 at low nanomolar concentrations and can induce Gi/o-dependent calcium mobilization, ERK1/2 activation, and monocyte chemotaxis. In experimental systems, FPR3 exhibits substantial basal phosphorylation and undergoes constitutive internalization, resulting in a predominantly intracellular distribution. F2L can modulate cytokine production and maturation in dendritic cells, although the physiological role of FPR3 in vivo remains incompletely understood. F2L is used as an experimental agonist to investigate FPR3 signaling. No FPR3-selective ligand has been reported to enter clinical trials or receive approval for therapeutic use. FPR3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine334/serine335 (pT334/pS335-FPR3) and threonine337/threonine339 (pT337/pT339-FPR3). This nomenclature refers to the human FPR3 receptor. For more information on FPR3 pharmacology please refer to the IUPHAR database. For further reading refer to:

 Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev. 2009 Jun;61(2):119-61. doi: 10.1124/pr.109.001578. Epub 2009 Jun 4. PMID: 19498085; PMCID: PMC2745437.