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Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 Antibodies

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Agonist-induced Serine355/Serine360 phosphorylation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7
pS355/pS360-ACKR3 (phospho-Atypical Chemokine...
Serine355/Serine360 (S355/S360) is major phosphorylation site of the Atypical Chemokine Receptor 3 (ACKR3, previously called CXCR7). The pS355/pS360-ACKR3 antibody detects phosphorylation in response to agonists. S355/S360...
$ 350.00 *
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SAMPLE PACK
Agonist-induced Serine355/Serine360 phosphorylation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7
ACKR3 Sample Pack (phospho- and...
ACKR3 Sample Pack consisting of all four available phospho- and non-phospho-Atypical Chemokine Receptor 3 Antibodies 4 x 20 µL trial size each. Specifically, this sample pack contains the following antibodies pS350/pT352-ACKR3...
$ 300.00 *
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NEW
Validation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 in transfected HEK293 cells
ACKR3 (non-phos, N-Term), Atypical Chemokine...
The non-phospho-ACKR3 receptor antibody is directed against the amino-terminal tail of mouse, rat and human ACKR3/CXCR7. It can be used to detect total ACKR3 receptors in Western blots independent of phosphorylation. The...
$ 250.00 *
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Citations
Validation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 in transfected HEK293 cells.
ACKR3 (non-phos, C-Term), Atypical Chemokine...
The non-phospho-ACKR3 receptor antibody is directed against the carboxyl-terminal tail of mouse, rat and human ACKR3/CXCR7. It can be used to detect total ACKR3 receptors in Western blots independent of phosphorylation. The...
$ 250.00 *
Details
Citations
pS350/pT352-ACKR3 (phospho-Atypical Chemokine Receptor 3 Antibody)
pS350/pT352-ACKR3 (phospho-Atypical Chemokine...
Serine350/Threonine352 (S350/T352) is major phosphorylation site of the Atypical Chemokine Receptor 3 (ACKR3, previously called CXCR7). The pS350/pT352-ACKR3 antibody detects phosphorylation in response to agonists and after PKC...
$ 350.00 *
Details

The atypical chemokine receptor 3 (ACKR3, previously called CXC chemokine receptor 7) is a member of the heptahelical receptor superfamily that sequesters its ligands CXCL11 and CXCL12 by highly efficient internalization. While ACKR3 does not engage heterotrimeric G proteins, it regulates the amount of ligand available for CXCR4. ACKR3 and CXCR4 cooperate in the regulation of many chemokine-dependent processes such as directed cell migration, immune homeostasis, inflammation and cancer. Efficient ligand sequestration by ACKR3 critically depends on GRK2 and GRK5 mediated phosphorylation of carboxyl-terminal serine350/threonine352 (pS350/pT352-ACKR3/CXCR7) and serine355/serine360 (pS355/pS360-ACKR3/CXCR7) but not on β-arrestin recruitment. This phosphorylation motif is highly conserved across a variety of species including mouse, rat and human. For more information on ACKR3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012 Aug 17;287(34):28362-77. doi: 10.1074/jbc.M111.335679. Epub 2012 Jun 26. PubMed PMID: 22736769; PubMed Central PMCID: PMC3436560.

The atypical chemokine receptor 3 (ACKR3, previously called CXC chemokine receptor 7) is a member of the heptahelical receptor superfamily that sequesters its ligands CXCL11 and CXCL12 by... read more »
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Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 Antibodies

The atypical chemokine receptor 3 (ACKR3, previously called CXC chemokine receptor 7) is a member of the heptahelical receptor superfamily that sequesters its ligands CXCL11 and CXCL12 by highly efficient internalization. While ACKR3 does not engage heterotrimeric G proteins, it regulates the amount of ligand available for CXCR4. ACKR3 and CXCR4 cooperate in the regulation of many chemokine-dependent processes such as directed cell migration, immune homeostasis, inflammation and cancer. Efficient ligand sequestration by ACKR3 critically depends on GRK2 and GRK5 mediated phosphorylation of carboxyl-terminal serine350/threonine352 (pS350/pT352-ACKR3/CXCR7) and serine355/serine360 (pS355/pS360-ACKR3/CXCR7) but not on β-arrestin recruitment. This phosphorylation motif is highly conserved across a variety of species including mouse, rat and human. For more information on ACKR3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012 Aug 17;287(34):28362-77. doi: 10.1074/jbc.M111.335679. Epub 2012 Jun 26. PubMed PMID: 22736769; PubMed Central PMCID: PMC3436560.

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