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Neuropeptide Y Receptor 1 Antibodies

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Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor 1
pT362/pS363-NPY1 (phospho-Neuropeptide Y...
Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y Receptor 1. The pT362/pS363-NPY1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation....
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NPY1

The NPY1 receptors couples to pertussis toxin-sensitive G proteins of the Gi or Go family. GR231118 is a NPY1 receptor-selective antagonist. NPY1 receptor desensitization and internalization are regulated by phosphorylation of carboxyl-terminal threonine362/serine363 (pT362/pS363-NPY1). This nomenclature refers to the human NPY1 receptor. This phosphorylation motif is highly conserved across species and is identical in mice, rats and humans but corresponds to pT361/pS362-NPY1 in mice and rats. For more information on NPY1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Beck-Sickinger, A., Colmers, W. F., Cox, H. M., Doods, H. N., Herzog, H., Larhammar, D., Michel, M. C., Quirion, R., Schwartz, T. and Westfall, T. (2019) “Neuropeptide Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F46/2019.4.

The NPY1 receptors couples to pertussis toxin-sensitive G proteins of the Gi or Go family. GR231118 is a NPY1 receptor-selective antagonist. NPY1 receptor desensitization and internalization... read more »
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Neuropeptide Y Receptor 1 Antibodies

NPY1

The NPY1 receptors couples to pertussis toxin-sensitive G proteins of the Gi or Go family. GR231118 is a NPY1 receptor-selective antagonist. NPY1 receptor desensitization and internalization are regulated by phosphorylation of carboxyl-terminal threonine362/serine363 (pT362/pS363-NPY1). This nomenclature refers to the human NPY1 receptor. This phosphorylation motif is highly conserved across species and is identical in mice, rats and humans but corresponds to pT361/pS362-NPY1 in mice and rats. For more information on NPY1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Beck-Sickinger, A., Colmers, W. F., Cox, H. M., Doods, H. N., Herzog, H., Larhammar, D., Michel, M. C., Quirion, R., Schwartz, T. and Westfall, T. (2019) “Neuropeptide Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F46/2019.4.

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