V2 Vasopressin Receptor Antibodies
The V2 receptor displays a high percentage identity with all other AVP/OT receptors. However, unlike the other receptors of the family, V1A, V1B and the OT receptor, it is primarily coupled to Gs, activation of adenylyl cyclase, production of cyclic AMP and activation of protein kinase A. The V2 receptor is secondarily coupled to Gq and a rise in cytosolic free calcium concentration, although with a much lower potency. The V2 receptor is exclusively expressed in the principal cells of the renal collecting duct, being responsible for the antidiuretic effect of AVP. Selective V2 agonists and antagonists have been described. Many natural mutations of the V2 receptor gene result in loss of function receptors leading to the X-linked congenital nephrogenic diabetes insipidus. People suffering from this disease do not concentrate urine and are characterized by polyuria. V2 receptor activity is regulated by phosphorylation of carboxyl-terminal serine350 (pS350-V2), threonine359/threonine360 (pT359/pT360-V2) and serine362/serine363/serine364 (pS362/pS363/pS364-V2). This nomenclature refers to the human V2 receptor. This phosphorylation motif is conserved across species and if highly homologous in mice and rats. For more information on V2 pharmacology please refer to the IUPHAR database. For further reading refer to:
Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin
"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi: 10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.
Bichet D, Bouvier M, Chini B, Gimpl G, Guillon G, Kimura T, Knepper M, Lolait S, Manning M, Mouillac B, O'Carroll AM, Serradeil-Le Gal C, Soloff M, Verbalis JG, Wheatley M, Zingg HH. Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).