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D1 Dopamine Receptor Antibodies

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Agonist-induced Serine372/Serine373 phosphorylation of the Dopamine Receptor 1
pS372/pS373-D1 (phospho-Dopamine Receptor 1...
Serine372/Serine373 (S372/S373) is a major phosphorylation site of the D1 receptor. The pS372/pS373-D1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S372/S373...
$ 375.00 *
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NEW
Agonist-induced Threonine354 phosphorylation of the Dopamine Receptor 1
pT354-D1 (phospho-Dopamine Receptor 1 Antibody)
Threonine354 (T354) is a major phosphorylation site of the D1 receptor. The pT354-D1 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T354 phosphorylation is a key regulator of D1...
$ 375.00 *
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Rabbit Monoclonal
NEW
Validation of the Dopamine Receptor 1 in transfected HEK293 cells
D1 [UMB10] (RM-non-phospho), Dopamine Receptor...
The non-phospho-D1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D1. It can be used to detect total D1 receptors in Western blots independent of phosphorylation. The non-phospho-D1 antibody...
$ 495.00 *
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NEW
Validation of the Dopamine Receptor 1 in transfected HEK293 cells
D1 (non-phospho-Dopamine Receptor 1 Antibody)
The non-phospho-D1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D1. It can be used to detect total D1 receptors in Western blots independent of phosphorylation. The non-phospho-D1 antibody...
$ 375.00 *
Details
Rabbit Monoclonal
NEW
Immunohistochemical identification of Dopamine Receptor 1 in striatum
D1 [UMB10] (RM-IHC-grade), Dopamine Receptor 1...
The non-phospho-D1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D1. It can be used to detect total D1 receptors in Western blots independent of phosphorylation. The non-phospho-D1 antibody...
$ 495.00 *
Details
NEW
Immunohistochemical identification of Dopamine Receptor 1 in striatum
D1 (IHC-grade), Dopamine Receptor 1 Antibody
The D1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D1. It can be used to detect total D1 receptors in Western blots independent of phosphorylation. The D1 antibody can also be used to...
$ 375.00 *
Details

 

 

D1aHGRSWzWKW1E1

The dopamine D₁ receptor (D₁R), encoded by DRD1, is a class A G protein-coupled receptor activated by the endogenous neurotransmitter dopamine. It couples primarily to Gs and Golf, stimulating adenylyl cyclase and increasing intracellular cAMP and protein kinase A activity. D₁R is abundant in the dorsal and ventral striatum and is also expressed in the cerebral cortex. In the dorsal striatum, it is enriched in direct-pathway spiny projection neurons, where it helps regulate movement and action selection. In the prefrontal cortex, D₁R signaling modulates working memory and other executive functions. Agonist stimulation can induce receptor phosphorylation, β-arrestin recruitment, and internalization, thereby regulating responsiveness to repeated or sustained dopamine exposure. Fenoldopam, a peripherally acting D₁-like agonist, is used intravenously for short-term blood pressure reduction in severe hypertension. Tavapadon, an oral D₁/D₅ partial agonist, is approved in the United States for the treatment of adults with Parkinson’s disease. D1 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine354 (pT354-D1), serine372/serine373 (pS372/pS373-D1). This nomenclature refers to the human D1. This phosphorylation motif is also present in mice and rats. For more information on D1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

    The dopamine D₁ receptor (D₁R), encoded by DRD1 , is a class A G protein-coupled receptor activated by the endogenous neurotransmitter dopamine. It couples primarily to Gs... read more »
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D1 Dopamine Receptor Antibodies

 

 

D1aHGRSWzWKW1E1

The dopamine D₁ receptor (D₁R), encoded by DRD1, is a class A G protein-coupled receptor activated by the endogenous neurotransmitter dopamine. It couples primarily to Gs and Golf, stimulating adenylyl cyclase and increasing intracellular cAMP and protein kinase A activity. D₁R is abundant in the dorsal and ventral striatum and is also expressed in the cerebral cortex. In the dorsal striatum, it is enriched in direct-pathway spiny projection neurons, where it helps regulate movement and action selection. In the prefrontal cortex, D₁R signaling modulates working memory and other executive functions. Agonist stimulation can induce receptor phosphorylation, β-arrestin recruitment, and internalization, thereby regulating responsiveness to repeated or sustained dopamine exposure. Fenoldopam, a peripherally acting D₁-like agonist, is used intravenously for short-term blood pressure reduction in severe hypertension. Tavapadon, an oral D₁/D₅ partial agonist, is approved in the United States for the treatment of adults with Parkinson’s disease. D1 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine354 (pT354-D1), serine372/serine373 (pS372/pS373-D1). This nomenclature refers to the human D1. This phosphorylation motif is also present in mice and rats. For more information on D1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

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