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Mas-related G-protein coupled receptors (MRGs) Antibodies

Mas-related GPCRs (MRGs) are activated by a diverse group of ligands that includes neuropeptides, cysteine proteases, antimicrobial peptides and cationic proteins released from activated eosinophils. Of the eight human MRGs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents. The cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is replaced in rodents with a family of MRG genes (>25 in mice, ~10 in rats) that have low homology to human MRGPRX genes. However, one of these mouse MRG genes (encoded by MrgprB2) has been proposed to be orthologous to human MRGPRX2, in that it shares tissue-distribution and as activated by most of the same agonists, and furthermore is encoded in a syntenic chromosomal locus. The low sequence similarity between MRGPRX2 and MrgprB2 is therefore surprising, but is attributed to frequent retrotransposon insertion into the locus in rodent.

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Agonist-induced Serine327/Serine328 phosphorylation of the MRGPRX2 Mas-related Receptor
pS327/pS328-MRGPRX2 (phospho-MRGPRX2...
Serine327/Serine328 (S327/S329) is a major phosphorylation site of the MRGPRX2 Mas-related receptor. The pS327/pS328-MRGPRX2 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation....
$ 375.00 *
NEW
Agonist-induced Serine313 phosphorylation of the MRGPRX2 Mas-related Receptor
pS313-MRGPRX2 (phospho-MRGPRX2 Mas-related...
Serine313 (S313) is a major phosphorylation site of the MRGPRX2 Mas-related receptor. The pS313-MRGPRX2 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S313 phosphorylation is a...
$ 375.00 *

For more information on neurotensin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

For more information on neurotensin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI,... read more »
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Mas-related G-protein coupled receptors (MRGs) Antibodies

For more information on neurotensin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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