Chemerin Receptor 1 Antibodies

Chemerin receptor 1 (CMKLR1, also known as ChemR23) is a class A G protein-coupled receptor activated by chemerin, an adipokine and chemoattractant. Chemerin is secreted as a weakly active precursor, and proteolytic processing of its C terminus generates forms with different potencies at CMKLR1. The receptor couples predominantly to Gi/o, inhibiting adenylyl cyclase, and can also recruit β-arrestins. CMKLR1 is expressed in adipose tissue, vascular smooth muscle, and several immune cell populations, including macrophages, dendritic cells, and natural killer cells. It mediates chemerin-directed immune cell migration and has been implicated in adipose tissue metabolism and vascular tone. Chemerin and its C-terminal nonapeptide C9 induce receptor internalization, and studies in recombinant cells have identified two C-terminal serine residues that contribute to this process. C9 is used experimentally as a chemerin-derived agonist, and CCX832 is a selective small-molecule CMKLR1 antagonist. No CMKLR1-selective drug is currently approved for therapeutic use. The Chemerin1 receptor is regulated by phosphorylation of carboxyl-terminal serine345/serine346 (pS345/pS346-CMKLR1), serine352/threonine354 (pS352/pT352-CMKLR1) and serine357/serine358 (pS357/pS358-CMKLR1). This nomenclature refers to the human CMKLR1. This phosphorylation motif is highly conserved across species and nearly identical in mice. Rats and humans. For more information on CMKLR1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Kennedy AJ, Davenport AP. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26. PMID: 29279348

Davenport AP, Monaghan AE. Chemerin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F338/2021.3.