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G protein-coupled recptors (GPCRs) and heptahelical receptors (7TMR) are notoriously difficult to detect in fixed tissues using antibodies. For many of these receptors the cellular and subcellular localization remains a major challenge. 7TM Antibodies provides highly-characterized protein binding reagents for selected human and rodent GPCRs, which are well suited for efficient localization in formalin-fixed, paraffin-embedded tissues. Each of these antibodies has gone through advanced validation in transfected cells and native tissues using Western blot and immunohistochemistry. Where ever species cross-reactivity allowed, the verification process included validation using knockout mice (KO-Validated). We strictly adhere to the IUPHAR guidelines for receptor nomenclature.

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Immunohistochemical identification of G Protein-coupled Receptor 17 in oligodendrocytes.

GPR17 (IHC-grade), G Protein-Coupled Receptor...

The GPR17 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The GPR17 antibody can...

$ 350.00 *

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Immunohistochemical identification of G Protein-coupled Receptor 84 in lymph node

GPR84 (IHC-grade), G Protein-Coupled Receptor...

The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...

$ 350.00 *

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Immunohistochemical identification of Dopamine Receptor 2 in hypothalamu

D2 (IHC-grade), Dopamine Receptor 2 Antibody

The D2 receptor antibody is directed against the third intracellular loop of mouse, rat and human D2 dopamine receptor. It detects both the long and short form of D2. It can be used to detect total D2 receptors in Western blots...

$ 350.00 *

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Validation of FLAG-tagged µ-Opioid Receptor in transfected HEK293 cells.

FLAG-Tag, Anti-FLAG Epitope Tag Antibody

The anti-FLAG tag antibody is directed against the sequence DYKDDDDK. The anti-FLAG antibody can be used to detect total receptors in Western blots independent of phosphorylation. The anti-FLAG tag antibody can also be used to isolate...

$ 150.00 *

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Immunohistochemical identification of Nociceptin/Orphanin FQ in mouse dorsal horn

N/OFQ (IHC-grade), Nociceptin/Orphanin FQ Antibody

The N/OFQ receptor antibody is directed against human Nociceptin/Orphanin FQ. The N/OFQ antibody can be used to detect N/OFQ in formalin-fixed, paraffin-embedded tissue sections by immunohistochemistry.

$ 350.00 *

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Immunohistochemical identification of Neuropeptide B (NPB) in rat hypothalamus

NPB (IHC-grade), Neuropeptide B Antibody

The NPB antibody is directed against human Neuropeptide B. The NPB antibody can be used to detect Neuropeptide B in formalin-fixed, paraffin-embedded tissue sections by immunohistochemistry.

$ 350.00 *

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Immunohistochemical control of anti-NPS (Neuropeptide S) antibody in mouse coronal sections

NPS (IHC-grade), Neuropeptide S Antibody

The NPS antibody is directed against human Neuropeptide S. The NPS antibody can be used to detect Neuropeptide S in formalin-fixed, paraffin-embedded tissue sections by immunohistochemistry.

$ 350.00 *

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KO-Validated

Immunohistochemical identification of Complement C5a Receptor 1 in human spleen.

mC5a1 (IHC-grade), Complement C5a Receptor 1...

The mouse C5a1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse and rat C5a1. It can be used to detect total C5a1 receptors in Western blots independent of phosphorylation. The mouse C5a1...

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C5a1 (IHC-grade), Complement C5a Receptor 1...

The C5a1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Complement 5a Receptor 1. It can be used to detect total C5a1 receptors in Western blots independent of phosphorylation. The C5a1...

$ 350.00 *

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Immunohistochemical identification of Atypical Chemokine Receptor 4 in human spleen.

ACKR4 (IHC-grade), Atypical Chemokine Receptor...

The ACKR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Atypical Chemokine Receptor 4. It can be used to detect total ACKR4 receptors in Western blots independent of phosphorylation. The...

$ 350.00 *

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KO-Validated

Immunohistochemical identification of G Protein-coupled Receptor 20 in mouse spleen.

mGPR20 (IHC-grade), G Protein-Coupled Receptor...

The GPR20 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse GPR20. It can be used to detect total GPR20 receptors in Western blots independent of phosphorylation. The GPR20 antibody can also be...

$ 350.00 *

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Immunohistochemical identification of G Protein-coupled Receptor 87 in kidney.

GPR87 (IHC-grade), G Protein-Coupled Receptor...

The GPR87 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP87. It can be used to detect total GPR87 receptors in Western blots independent of phosphorylation. The GPR87 antibody can...

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Immunohistochemical identification of Growth Hormone-Releasing Hormone Receptor in breast carcinoma.

GHRHR (IHC-grade), GHRH Receptor Antibody

The GHRH receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Growth Hormone-Releasing Hormone Receptor. It detects the canonical form of GHRHR as well as the amino-terminal splice variant SV1. It...

$ 350.00 *

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KO-Validated

Immunohistochemical identification of VIP Receptor 2 in small intestine.

VPAC2 (IHC-grade), VIP Receptor 2 Antibody

The VPAC2 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human VIP receptor 2. It can be used to detect total VPAC2 receptors in Western blots independent of phosphorylation. The VPAC2...

$ 350.00 *

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Immunohistochemical identification of Bombesin Receptor 2/Gastrin-Relasing Peptide Receptor (BB2/GRPR) in human breast carcinoma.

BB2 (IHC-grade), Bombesin Receptor...

The BB2/GRPR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Bombesin Receptor 2 (previously called Gastrin-Releasing Peptide Receptor). It can be used to detect total BB2 receptors in Western...

$ 350.00 *

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KO-Validated

Immunohistochemical identification of µ-Opioid Receptor in caudate putamen.

MOP (IHC-grade), µ-Opioid Receptor Antibody

The µ-Opioid Receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human MOP. It detects selectively the canonical form of MOP and none of the putative splice variants. In can be used to...

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For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-2 4. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

For further reading refer to: Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the... read more »

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For further reading refer to: