Apelin Receptor Antibodies
The apelin receptor (APLNR) responds to apelin, a 36 amino-acid peptide which is cleaved from a 77 amino-acid precursor peptide. Apelin-36, apelin-13 and [Pyr1]apelin-13 are the predominant endogenous ligands. A second family of peptides named Elabela/Toddler has discovered independently as endogenous ligands. The capelin receptor is coupled to inhibitory G-proteins. A number of physiological roles for the receptor have emerged, including regulation of cardiovascular function, fluid homeostasis, the adipoinsular axis, gastrointestinal and immunomodulatory functions. APLNR receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine347/serine348 (pS347/pS348-APLNR). This nomenclature refers to human APLNR. This phosphorylation motif is highly conserved across species but corresponds to pS345/pS346-APLNR in mice and rats. For more information on APLNR pharmacology please refer to the IUPHAR database. For further reading refer to:
Pitkin SL, Maguire JJ, Bonner TI, Davenport AP. International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function. Pharmacol Rev. 2010 Sep;62(3):331-42. doi: 10.1124/pr.110.002949. Epub 2010 Jul 6. PMID: 20605969.