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Sphingosine 1-Phosphate Receptor 2 Antibodies

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Agonist-induced Serine330/Serine331 phosphorylation of the Sphingosine 1-Phosphate Receptor 2
pS330/pS331-S1P2 (phospho-Sphingosine...
Serine330/Serine331 (S330/S331) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 2 (S1P2). The pS330/pS331-S1P2 antibody detects phosphorylation in response to agonists. S330/S331 phosphorylation is likely to be...
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pT342/pS343/pT345-S1P2 (phospho-Sphingosine 1-Phosphate Receptor 2 Antibody)
pT342/pS343/pT345-S1P2 (phospho-Sphingosine...
Threonine342Serine343/Threonine345 (T342/S343/T345) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 2 (S1P2). The pT342/pS343/pT345-S1P2 antibody detects phosphorylation in response to agonists. T342/S343/T345...
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Activation of S1P2 receptors has pro-inflammatory effects such as mast cell degranulation and production of pro-inflammatory cytokines. In human cord blood mast cells, S1P2 positively regulates allergen-induced degranulation and chemokine release. S1P2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine330/serine331 (pS330/pS331-S1P2) and threonine342/serine343 (pT342/pS343-S1P2). This nomenclature refers to the human S1P2 receptor. This phosphorylation motif is highly conserved across species and is identical mice, rats and humans. For more information on S1P2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

Activation of S1P2 receptors has pro-inflammatory effects such as mast cell degranulation and production of pro-inflammatory cytokines. In human cord blood mast cells, S1P2 positively... read more »
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Sphingosine 1-Phosphate Receptor 2 Antibodies

Activation of S1P2 receptors has pro-inflammatory effects such as mast cell degranulation and production of pro-inflammatory cytokines. In human cord blood mast cells, S1P2 positively regulates allergen-induced degranulation and chemokine release. S1P2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine330/serine331 (pS330/pS331-S1P2) and threonine342/serine343 (pT342/pS343-S1P2). This nomenclature refers to the human S1P2 receptor. This phosphorylation motif is highly conserved across species and is identical mice, rats and humans. For more information on S1P2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

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