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Sphingosine 1-Phosphate Receptor 4 Antibodies

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Agonist-induced Serine364/Serine366/Serine368 phosphorylation of the Sphingosine 1-Phosphate Receptor 4
pS364/pS366/pS368-S1P4 (phospho-Sphingosine...
Serine364/Serine366/Serine368 (S364/S366/S368) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 4 (S1P4). The pS364/pS366/pS368-S1P4 antibody detects phosphorylation in response to agonists. S364/S366/S368...
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S1P4 receptors are expressed in spleen, peripheral leukocytes, lung, thymus, lymph node, bone marrow.  Loss of S1P4 impairs splenic germinal center response to sepsis and results in abnormal megakaryocyte morphology. S1P4 receptors are regulated by phosphorylation of carboxyl-terminal serine364/serine344/serine368 (pS364/pS366/pS368-S1P4). This nomenclature refers to the human S1P4 receptor. This phosphorylation motif is conserved across species and similar in mice, rats and humans. For more information on S1P4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

S1P4 receptors are expressed in spleen, peripheral leukocytes, lung, thymus, lymph node, bone marrow.  Loss of S1P4 impairs splenic germinal center response to sepsis and results in... read more »
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Sphingosine 1-Phosphate Receptor 4 Antibodies

S1P4 receptors are expressed in spleen, peripheral leukocytes, lung, thymus, lymph node, bone marrow.  Loss of S1P4 impairs splenic germinal center response to sepsis and results in abnormal megakaryocyte morphology. S1P4 receptors are regulated by phosphorylation of carboxyl-terminal serine364/serine344/serine368 (pS364/pS366/pS368-S1P4). This nomenclature refers to the human S1P4 receptor. This phosphorylation motif is conserved across species and similar in mice, rats and humans. For more information on S1P4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

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