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M2 Muscarinic Acetylcholine Receptors Antibodies

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Agonist-induced Threonine271 phosphorylation of the M2 Muscarinic Acetycholine Receptor
pT271-M2 (phospho-M2 Muscarinic Acetylcholine...
Threonine271 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pT271-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T271 phosphorylation is a key...
$ 350.00
NEW
Agonist-induced Serine282/Serine283 phosphorylation of the M2 Muscarinic Acetylcholine Receptor
pS282/pS283-M2 (phospho-M2 Muscarinic...
Serine282/Serine283 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pS282/pS283-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S282/S283...
$ 350.00
NEW
Agonist-induced Serine286/Threonine287/Serine288 phosphorylation of the M2 Muscarinic Acetycholine Receptor
pS286/pT287/pS288-M2 (phospho-M2 Muscarinic...
Serine286/Threonine287/Serine288 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pS286/pT287/pS288-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation....
$ 350.00
NEW
Agonist-induced Threonine307/Serine309 phosphorylation of the M2 Muscarinic Acetylcholine Receptor
pT307/pS309-M2 (phospho-M2 Muscarinic...
Threonine307/Serine309 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pT307/pS309-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T307/S309...
$ 350.00
NEW
Agonist-induced Threonine310/Serine311 phosphorylation of the M2 Muscarinic Acetycholine Receptor
pT310/pS311-M2 (phospho-M2 Muscarinic...
Threonine310/Serine311 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pT310/pS311-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T310/S311...
$ 350.00
NEW
Agonist-induced Serine315/Serine320 phosphorylation of the M2 Muscarinic Acetycholine Receptor
pS315/pS320-M2 (phospho-M2 Muscarinic...
Serine315/Serine320 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pS315/pS320-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S315/S320...
$ 350.00
NEW
Validation of the M2 Muscarinic Acetylcholine Receptor in transfected HEK293 cells
M2 (non-phospho-M2 Muscarinic Acetylcholine...
The non-phospho-M2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human M2 Muscarinic Acetylcholine Receptor (M2). It can be used to detect total M2 receptors in Western blots independent of...
$ 250.00

Functionally, M2 muscarinic receptors are able to couple to the pertusiss toxin-sensitive Gi/o-proteins. M2 receptors are expressed in the heart where they have a profound role in the control of cardiac myocyte contraction. In fact, acetylcholine released from vagal parasympathetic neurones reduces heart beating frequency almost exclusively by acting at M2 muscarinic receptors. M2 receptor activity is regulated by phosphorylation of serine271, serine282/serine283, serine286/threonine287/serine288, threonine307/serine309, threonine310/serine311, serine315/serine320 in the 3rd intracellular loop. This nomenclature refers to the human M1 but is highly conserved in mice and rats. For more information on M2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998 Jun;50(2):279-90. PMID: 9647869.

Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007 Sep;6(9):721-33. doi: 10.1038/nrd2379. PMID: 17762886.

Birdsall NJM, Bradley S, Brown DA, Buckley NJ, Challiss RJ, Christopoulos A, Eglen RM, Ehlert F, Felder CC, Hammer R, Kilbinger HJ, Lambrecht G, Langmead C, Mitchelson F, Mutschler E, Nathanson NM, Schwarz RD, Thal D, Tobin AB, Valant C, Wess J. Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(3).

Functionally, M2 muscarinic receptors are able to couple to the pertusiss toxin-sensitive Gi/o-proteins. M2 receptors are expressed in the heart where they have a profound role in the control... read more »
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M2 Muscarinic Acetylcholine Receptors Antibodies

Functionally, M2 muscarinic receptors are able to couple to the pertusiss toxin-sensitive Gi/o-proteins. M2 receptors are expressed in the heart where they have a profound role in the control of cardiac myocyte contraction. In fact, acetylcholine released from vagal parasympathetic neurones reduces heart beating frequency almost exclusively by acting at M2 muscarinic receptors. M2 receptor activity is regulated by phosphorylation of serine271, serine282/serine283, serine286/threonine287/serine288, threonine307/serine309, threonine310/serine311, serine315/serine320 in the 3rd intracellular loop. This nomenclature refers to the human M1 but is highly conserved in mice and rats. For more information on M2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998 Jun;50(2):279-90. PMID: 9647869.

Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007 Sep;6(9):721-33. doi: 10.1038/nrd2379. PMID: 17762886.

Birdsall NJM, Bradley S, Brown DA, Buckley NJ, Challiss RJ, Christopoulos A, Eglen RM, Ehlert F, Felder CC, Hammer R, Kilbinger HJ, Lambrecht G, Langmead C, Mitchelson F, Mutschler E, Nathanson NM, Schwarz RD, Thal D, Tobin AB, Valant C, Wess J. Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(3).

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